| Title: |
Introduction to Pharmaceutical Co-Amorphous Systems Using a Green Co-Milling Technique |
| Language: |
English |
| Authors: |
Joana F. C. Silva; Ma´rio T. S. Rosado (ORCID 0000-0001-5782-8819); Teresa M. R. Maria; Pedro S. Pereira Silva; Manuela Ramos Silva (ORCID 0000-0001-9555-8856); M. Ermelinda S. Euse´bio (ORCID 0000-0002-5515-7721) |
| Source: |
Journal of Chemical Education. 2023 100(4):1627-1632. |
| Availability: |
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc |
| Peer Reviewed: |
Y |
| Page Count: |
6 |
| Publication Date: |
2023 |
| Document Type: |
Journal Articles; Reports - Descriptive |
| Education Level: |
Higher Education; Postsecondary Education |
| Descriptors: |
Laboratory Experiments; Chemistry; Science Instruction; Pharmacology; Science Curriculum; Masters Programs; Sustainability; Scientific Concepts; Science Experiments; Science Laboratories; Laboratory Procedures; Technology; Equipment |
| ISSN: |
0021-9584; 1938-1328 |
| Abstract: |
The concept of co-amorphous systems is introduced in an integrated laboratory experiment, designed for advanced chemistry students, using solvent-free, environmentally friendly mechanochemistry. The dual-drug naproxen-cimetidine co-amorphous system (NPX-CIM) is investigated as an example of the emergent field of medicinal mechanochemistry. Students are trained in solid-state characterization techniques including X-ray powder diffraction, Fourier-transform infrared spectroscopy, and thermal analysis by differential scanning calorimetry. This lab experiment also provides an opportunity to discuss the relevance of different solid forms of pharmaceutics, emphasizing particular properties of disordered materials. This experiment can easily fit the curriculum of any Chemistry or Pharmacy master level degree in courses dealing with instrumental analysis, solid state chemistry, or green chemistry, for classes of 6 to 18 students, in a 5-h lab session. Suggestions to adapt it to the use of a single characterization technique are provided. |
| Abstractor: |
As Provided |
| Entry Date: |
2024 |
| Accession Number: |
EJ1444517 |
| Database: |
ERIC |