| Title: |
Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years |
| Language: |
English |
| Authors: |
Irene Campos-Sánchez; Eva María Navarrete-Muñoz (ORCID 0000-0002-1494-5676); Dries S. Martens; Isolina Riaño-Galán; Aitana Lertxundi; Sabrina Llop; Mónica Guxens; Cristina Rodríguez-Dehli (ORCID 0009-0007-0140-7717); Nerea Lertxundi; Raquel Soler-Blasco; Martine Vrijheid; Tim S. Nawrot; John Wright; Tiffany C. Yang; Rosie McEachan; Kristine Bjerve Gützkow; Vaia Lida Chatzi; Marina Vafeiadi; Mariza Kampouri; Regina Grazuleviciene; Sandra Andrusaityte; Johanna Lepeule (ORCID 0000-0001-8907-197X); Desirée Valera-Gran (ORCID 0000-0001-6388-127X) |
| Source: |
Journal of Attention Disorders. 2025 29(6):474-485. |
| Availability: |
SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Peer Reviewed: |
Y |
| Page Count: |
12 |
| Publication Date: |
2025 |
| Document Type: |
Journal Articles; Reports - Research |
| Education Level: |
Elementary Education; Junior High Schools; Middle Schools; Secondary Education |
| Descriptors: |
Foreign Countries; Genetic Disorders; Attention Deficit Hyperactivity Disorder; Mothers; Elementary School Students; Middle School Students; Symptoms (Individual Disorders); Neurodevelopmental Disorders; Genetics; Causal Models |
| Geographic Terms: |
United Kingdom; Greece; Spain; Norway; France; Lithuania |
| DOI: |
10.1177/10870547251314923 |
| ISSN: |
1087-0547; 1557-1246 |
| Abstract: |
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years. Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations. Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = 0.022). Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail. |
| Abstractor: |
As Provided |
| Entry Date: |
2025 |
| Accession Number: |
EJ1467296 |
| Database: |
ERIC |