| Title: |
Prenatal Stress and Socioeconomic Status as Predictors of Placental Methylation in Pregnant People |
| Language: |
English |
| Authors: |
Czenilriene J. Santander; Sharon Y. Lee; Gloria Peters; Carmen J. Marsit; Laura R. Stroud |
| Source: |
Merrill-Palmer Quarterly: A Peer Relations Journal. 2024 70(3):477-497. |
| Availability: |
Wayne State University Press. The Leonard N. Simons Building, 4809 Woodward Avenue, Detroit, MI 48201-1309. Tel: 800-978-7323; Fax: 313-577-6131; Web site: https://digitalcommons.wayne.edu/mpq/ |
| Peer Reviewed: |
Y |
| Page Count: |
21 |
| Publication Date: |
2024 |
| Sponsoring Agency: |
National Institutes of Health (NIH) (DHHS) |
| Contract Number: |
R01DA031188; R01DA044504 |
| Document Type: |
Journal Articles; Reports - Research |
| Descriptors: |
Stress Variables; Pregnancy; Socioeconomic Status; Prenatal Influences; Correlation; Family Income; Prediction; Genetics; Biochemistry; Smoking; Gender Differences; Mothers; Prenatal Care; Age Differences; Infants |
| Assessment and Survey Identifiers: |
Hollingshead Social Economic Status Measures |
| ISSN: |
0272-930X; 1535-0266 |
| Abstract: |
Despite growing interest in placental epigenetics, the combined impact of prenatal stress and socioeconomic status on placental methylation is still largely understudied. We conducted a study to examine the associations of prenatal stress and socioeconomic factors (household income, Hollingshead socioeconomic index) with placental methylation. Pregnant people (n = 143; M[subscript age] = 25.66) in their second or third trimester (M[subscript gestational age] = 23.11 weeks) completed self-report questionnaires including demographic and socioeconomic information and ratings of perceived stress in the past month. Placenta tissue samples were collected after birth, from which placental genomic DNA was extracted to assess methylation levels at the "NR3C1" promoter region. Multiple regression analyses were conducted, with prenatal stress, household income, and Hollingshead index predicting methylation at the different CpG glucocorticoid receptor sites, controlling for maternal age, smoking status, gestational age at delivery, and infant sex. Prenatal stress predicted "NR3C1" methylation at the CpG8 and CpG9 glucocorticoid receptor sites. Household income was a significant predictor of methylation at the CpG9 site. Hollingshead index was not associated with methylation at any site. The independent effects of prenatal stress and socioeconomic status demonstrate the need for health care providers to recognize the psychological and socioeconomic influences on maternal-fetal health. |
| Abstractor: |
As Provided |
| Entry Date: |
2025 |
| Access URL: |
https://digitalcommons.wayne.edu/mpq/vol70/iss3/5 |
| Accession Number: |
EJ1469590 |
| Database: |
ERIC |