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The Mixed Subjects Design: Treating Large Language Models as Potentially Informative Observations

Title: The Mixed Subjects Design: Treating Large Language Models as Potentially Informative Observations
Language: English
Authors: David Broska (ORCID 0000-0002-5176-1163); Michael Howes (ORCID 0009-0007-8048-3397); Austin van Loon (ORCID 0000-0002-9565-7392)
Source: Sociological Methods & Research. 2025 54(3):1074-1109.
Availability: SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com
Peer Reviewed: Y
Page Count: 36
Publication Date: 2025
Document Type: Journal Articles; Reports - Research
Descriptors: Artificial Intelligence; Observation; Prediction; Correlation; Sample Size; Statistical Analysis; Social Science Research; Statistical Inference; Research Design
DOI: 10.1177/00491241251326865
ISSN: 0049-1241; 1552-8294
Abstract: Large language models (LLMs) provide cost-effective but possibly inaccurate predictions of human behavior. Despite growing evidence that predicted and observed behavior are often not "interchangeable," there is limited guidance on using LLMs to obtain valid estimates of causal effects and other parameters. We argue that LLM predictions should be treated as potentially informative observations, while human subjects serve as a gold standard in a "mixed subjects design." This paradigm preserves validity and offers more precise estimates at a lower cost than experiments relying exclusively on human subjects. We demonstrate--and extend--prediction-powered inference (PPI), a method that combines predictions and observations. We define the "PPI correlation" as a measure of interchangeability and derive the "effective sample size" for PPI. We also introduce a power analysis to optimally choose between "informative but costly" human subjects and "less informative but cheap" predictions of human behavior. Mixed subjects designs could enhance scientific productivity and reduce inequality in access to costly evidence.
Abstractor: As Provided
Entry Date: 2025
Accession Number: EJ1475702
Database: ERIC