| Title: |
Contributions of the ELENA Cohort to Study Autism Spectrum Disorder in Children and Adolescents from a Biopsychosocial Framework |
| Language: |
English |
| Authors: |
Amaria Baghdadli (ORCID 0000-0002-5679-7544); Marianne Peries (ORCID 0000-0002-6791-4419); Julie Loubersac (ORCID 0000-0002-2771-0577); Cécile Michelon; Cécile Rattaz; Laetitia Ferrando; Aurore David; Kerim Munir (ORCID 0000-0002-2404-1806); Marie-Christine Picot (ORCID 0000-0003-4204-7299) |
| Source: |
Journal of Autism and Developmental Disorders. 2026 56(1):362-387. |
| Availability: |
Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Peer Reviewed: |
Y |
| Page Count: |
26 |
| Publication Date: |
2026 |
| Document Type: |
Journal Articles; Reports - Research |
| Descriptors: |
Cohort Analysis; Autism Spectrum Disorders; Children; Adolescents; Profiles; Foreign Countries; Risk; Environmental Influences; Psychological Patterns; Social Influences; Pregnancy; Early Experience; Severity (of Disability); Comorbidity; Quality of Life; Intervention; Well Being |
| Geographic Terms: |
France |
| DOI: |
10.1007/s10803-024-06519-8 |
| ISSN: |
0162-3257; 1573-3432 |
| Abstract: |
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by a myriad of developmental, biological, psychological, and socio-demographic factors. The ELENA cohort seeks to delineate the intricate interplay of these factors, facilitating the identification of risk factors and the development of targeted interventions. This paper emphasizes the clinical profiles of children and outlines key findings from a biopsychosocial perspective. The ELENA cohort, a multicenter initiative across French regional centers, conducted a systematic prospective analysis on children newly diagnosed with DSM-5 ASD between 2012 and 2019. This encompassed direct assessments and parent-reported questionnaires covering a broad spectrum of developmental, biological, psychological and socio-demographic measures. Embedded case-control studies further examined risk and protective factors, alongside specific environmental and psychosocial influences during pregnancy and early childhood. A subset of participants also contributed biospecimens, with data enhancement via linkage to French National Administrative Healthcare Databases. The study unveils baseline clinical characteristics for 876 children, average age 6 (SD ± 3.3) previously unreported in protocol descriptions. It highlights the study's developmental biopsychosocial approach and its novel findings on children's socio-adaptive functioning, ASD severity, comorbidities, quality of life and interventions. Employing developmental biopsychosocial insights offers a promising pathway to integrating health, social care, and experiential insights, ultimately aiming to enhance the future well-being and outcomes for children with ASD. This approach underscores the need of a holistic, interdisciplinary strategy in encouraging and supporting the ASD community. |
| Abstractor: |
As Provided |
| Entry Date: |
2026 |
| Accession Number: |
EJ1504740 |
| Database: |
ERIC |