| Title: |
Effects of Topiramate in Adults with Prader-Willi Syndrome |
| Language: |
English |
| Authors: |
Shapira, Nathan A.; Lessig, Mary C.; Lewis, Mark H. |
| Source: |
American Journal on Mental Retardation. 2004 109(4):301-309. |
| Availability: |
American Association on Mental Retardation. P.O. Box 7065, Lawrence, KS 66044-7065. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://www.aamr.org/Periodicals/index.shtml. |
| Peer Reviewed: |
Y |
| Page Count: |
9 |
| Publication Date: |
2004 |
| Document Type: |
Journal Articles; Reports - Research |
| Descriptors: |
Obesity; Moderate Mental Retardation; Adults; Eating Disorders; Self Destructive Behavior; Drug Therapy; Behavior Patterns; Food; Measures (Individuals); Body Composition; Medical Evaluation; Outcomes of Treatment |
| ISSN: |
0895-8017 |
| Abstract: |
Prader-Willi syndrome is a multisystem neurogenetic obesity disorder with behavioral manifestations, including hyperphagia, compulsive behavior, self-injury, and mild to moderate mental retardation. In an 8-week open-label study, we evaluated adjunctive therapy with the anticonvulsant topiramate in 8 adults with Prader-Willi syndrome. Appetite was measured by a 1-hour access to food four times throughout the study and quantified with a visual analogue scale. Topiramate did not significantly change calories consumed, Body Mass Index, or increase self-reported appetite. In addition, there were no significant changes in compulsions. Surprisingly, topiramate treatment resulted in a clinically significant improvement in the self-injury (i.e., skin-picking) that is characteristic of this syndrome. Potential benefits of topiramate for self-injury should be evaluated further in controlled trials. |
| Abstractor: |
Author |
| Entry Date: |
2006 |
| Accession Number: |
EJ742639 |
| Database: |
ERIC |