| Title: |
Coaction of Stress and Serotonin Transporter Genotype in Predicting Aggression at the Transition to Adulthood |
| Language: |
English |
| Authors: |
Conway, Christopher C.; Keenan-Miller, Danielle; Hammen, Constance; Lind, Penelope A.; Najman, Jake M.; Brennan, Patricia A. |
| Source: |
Journal of Clinical Child and Adolescent Psychology. 2012 41(1):53-63. |
| Availability: |
Routledge. Available from: Taylor & Francis, Ltd. 325 Chestnut Street Suite 800, Philadelphia, PA 19106. Tel: 800-354-1420; Fax: 215-625-2940; Web site: http://www.tandf.co.uk/journals |
| Peer Reviewed: |
Y |
| Page Count: |
11 |
| Publication Date: |
2012 |
| Document Type: |
Journal Articles; Reports - Research |
| Descriptors: |
Structural Equation Models; Chemistry; Investigations; Adults; Adolescents; Foreign Countries; Age Differences; Aggression; Individual Differences; Interviews; Genetics; Science Education; Whites; Minority Groups; Prediction |
| Geographic Terms: |
Australia |
| DOI: |
10.1080/15374416.2012.632351 |
| ISSN: |
1537-4416 |
| Abstract: |
Despite consistent evidence that serotonin functioning affects stress reactivity and vulnerability to aggression, research on serotonin gene-stress interactions (G x E) in the development of aggression remains limited. The present study investigated variation in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-aggression association at the transition to adulthood. Multiple informants and multiple measures were used to assess aggression in a cohort of 381 Australian youth (61% female, 93% Caucasian) interviewed at ages 15 and 20. At age 20, semistructured interviews assessed acute and chronic stressors occurring in the past 12 months. Structural equation modeling analyses revealed a significant main effect of chronic stress, but not 5-HTTLPR or acute stress, on increases in aggression at age 20. Consistent with G x E hypotheses, 5-HTTLPR short allele carriers demonstrated greater increments in aggression following chronic stress relative to long allele homozygotes. The strength of chronic stress G x E did not vary according to sex. Variation at 5-HTTLPR appears to contribute to individual differences in aggressive reactions to chronic stress at the transition to adulthood. (Contains 2 tables, 2 figures, and 3 footnotes.) |
| Abstractor: |
As Provided |
| Number of References: |
56 |
| Entry Date: |
2012 |
| Accession Number: |
EJ956523 |
| Database: |
ERIC |