Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B
| Title: | Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B |
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| Authors: | Crawforth, James Michael |
| Summary: | Homochiral (S)-(-)-paraconic acid was synthesised in 18% overall yield from (45)-4-isopropyl-2-oxazolidinone using titanium enolate methodology. Paraconic acid was used to synthesise A-factor. A-factor and analogues were fed to a culture of Streptomyces nodosus however no definitive enhancement, or a decrease in the lag time for the onset of metabolite production was observed. Sodium acetate-d3, [1-13C] and [3-13C]-propionate were fed to a culture of Streptomyces nodosus and label incorporation into amphotericin B of 10-15% was observed. |
| URL: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674435 |
| Database: | OpenDissertations |