| Title: |
Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy |
| Authors: |
Meij, Anika S; Van Stee, Lucinda Luvia; Kruitwagen, Hedwig S; van Nieuwaal-Jubbega, Robert Cornelis; Grinwis, Guy C M; Galac, Sara; Meij, Björn P; Chirurgie; Interne geneeskunde GD; Welfare & Emerging Diseases; VPDC pathologie; Pathology; OnGo; CS_Cancer; Locomotion - Surgery (CA); CS_Locomotion |
| Publication Year: |
2026 |
| Subject Terms: |
acromegaly; diabetes mellitus; growth hormone; pituitary adenoma; veterinary neurosurgery; General Veterinary; SDG 3 - Good Health and Well-being |
| Description: |
BACKGROUND: Pituitary somatotroph adenoma is rare in dogs and may cause hypersomatotropism (HS) leading to insulin resistance and diabetes mellitus (DM). CASE DESCRIPTION: A 10-year-5-month-old neutered male Staffordshire Bull Terrier presented with polyuria, polydipsia, progressive inspiratory stridor, and poorly controlled DM with hyperinsulinemia and insulin resistance. Serum insulin-like growth factor (IGF-1) was markedly elevated (1,214 ng/mL; reference interval, 42-449 ng/mL) and suggested HS which was further supported by a somatostatin suppression test. Magnetic resonance and computed tomography (CT) imaging revealed a pituitary mass, organomegaly, and arthropathy. TREATMENT AND OUTCOME: The pituitary mass was removed by transsphenoidal hypophysectomy. Immunohistochemistry confirmed a growth hormone (GH)-producing pituitary adenoma. Postoperatively, GH normalized within hours, and IGF-1 values within a week. Although HS resolved and hyperinsulinemia improved postoperatively, the dog remained dependent on insulin and DM persisted which eventually led to euthanasia of the dog about 9 and a half months post-operatively. CONCLUSION: Transsphenoidal hypophysectomy was effective in normalization of GH and IGF-1 concentrations in a dog diagnosed with a pituitary somatotroph adenoma but the postoperative course was characterized by persistent insulin dependency and DM. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2297-1769 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/481095 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/481095 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.102D0F00 |
| Database: |
BASE |