| Title: |
Prognostic impact of the number and Temporality of heart failure Hospitalisations: Analysis of a National healthcare database |
| Authors: |
Logeart, Damien; Roubille, François; Salvat, Muriel; Tribouilloy, Christophe; Bauer, Fabrice; Eicher, Jean-Christophe; Picard, François; von Hunolstein, Jean-Jacques; Trochu, Jean-Noël; de Groote, Pascal; Berthelot, Emmanuelle; Fagnani, Francis; Batel, Leila; Doublet, Maxime; Damy, Thibaud; Isnard, Richard |
| Contributors: |
Hôpital Lariboisière-Fernand-Widal APHP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; Hôpital Arnaud de Villeneuve CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Hôpital Michallon; Service de Cardiologie Amiens; CHU Amiens-Picardie; Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 (MP3CV); Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie; Hôpital Charles Nicolle Rouen; CHU Rouen; Normandie Université (NU)-Normandie Université (NU); Hôpital du Bocage; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Hôpital Haut-Lévêque CHU Bordeaux; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux); Nouvel Hôpital Civil de Strasbourg; Hôpitaux Universitaires de Strasbourg (HUS); Hôpital Guillaume-et-René-Laennec CHU Nantes; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hôpital Bicêtre GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-GHU AP-HP. Université Paris Saclay; Cemka-eval; Bayer S.A.S. France; Bayer AG Germany; Clinityx; IMRB - CEPIA/"Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health" Créteil (U955 Inserm - UPEC); Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Hôpital Henri Mondor; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor Créteil; Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Henri Mondor-Albert Chenevier-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Sorbonne Université (SU); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Source: |
ISSN: 2352-9067 ; International Journal of Cardiology. Heart & Vasculature ; https://u-picardie.hal.science/hal-05369657 ; International Journal of Cardiology. Heart & Vasculature, 2025, 61, pp.101833. ⟨10.1016/j.ijcha.2025.101833⟩. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2025 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
Worsening heart failure; Reduced ejection fraction; Hospitalisation; Mortality; Real-world evidence; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| Description: |
International audience ; Aims: To assess the prognostic impact of both the frequency and timing of prior heart failure (HF) hospitalisations on outcomes in patients with reduced left ventricular ejection fraction (LVEF).Methods and results : This nationwide retrospective cohort study used the French national health insurance database to identify 730,052 adults with HF in 2017. A validated algorithm classified 226,747 as HF with reduced LVEF (24 h within the preceding 24 months (worsening HF group). Patients were stratified by (1) time since the last HF hospitalisation (0–6, 6–24 months) and (2) number of hospitalisations (1, 2, ≥3). Mean age was 76 ± 15 years. Prior HF hospitalisation was the strongest predictor of mortality among all variables. After multivariable adjustment, prior hospitalisation was associated with increased risk of all-cause death (HR 1.61, 95 % CI 1.56–1.65), all-cause hospitalisation (HR 1.34, 95 % CI 1.32–1.37), and recurrent HF hospitalisation (HR 2.51, 95 % CI 2.43–2.59). Risks were greatest when the most recent hospitalisation occurred within 6 months and rose progressively with the number of prior events.Conclusion : In patients with reduced LVEF, both recent and recurrent HF hospitalisations are strong predictors of mortality and rehospitalisation. These two simple markers identify highly vulnerable patients and should trigger intensified follow-up, optimisation of guideline-directed therapies, and implementation of transitional care and remote monitoring programs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/j.ijcha.2025.101833 |
| Availability: |
https://u-picardie.hal.science/hal-05369657; https://u-picardie.hal.science/hal-05369657v1/document; https://u-picardie.hal.science/hal-05369657v1/file/1-s2.0-S2352906725002362-main.pdf; https://doi.org/10.1016/j.ijcha.2025.101833 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.1050652F |
| Database: |
BASE |