| Title: |
High-grade vaginal intraepithelial neoplasia and risk of progression to vaginal cancer. a multicentre study of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV) |
| Authors: |
Sopracordevole F; Barbero M; Clemente N; Fallani MG; Cattani P; Agarossi A; De Piero G; Parin A; FREGA, Antonio; Boselli F; Mancioli F; Buttignol M; Currado F; Pieralli A; Ciavattini A; Italian Society of Colposcopy; Cervico Vaginal Pathology |
| Contributors: |
Sopracordevole, F; Barbero, M; Clemente, N; Fallani, Mg; Cattani, P; Agarossi, A; De Piero, G; Parin, A; Frega, Antonio; Boselli, F; Mancioli, F; Buttignol, M; Currado, F; Pieralli, A; Ciavattini, A; Italian Society of, Colposcopy; Cervico Vaginal, Pathology |
| Publisher Information: |
Verduci Editore; Roma Italy |
| Publication Year: |
2016 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
vaginal intraepithelial neoplasia; vain; vaginal cancer |
| Description: |
OBJECTIVE: The aim of this study was to analyse the women with high grade vaginal intraepithelial neoplasia (HG-VaIN), in order to identify a subset of women at higher risk of progression to invasive vaginal cancer. MATERIALS AND METHODS: The medical records of all the women diagnosed with HG-VaIN, and subsequently treated, from January 1995 to December 2013 were analyzed in a multicentre retrospective case series. The rate of progression to invasive vaginal cancer and the potential risk factors were evaluated. RESULTS: 205 women with biopsy diagnosis of HG-VaIN were considered, with a mean follow up of 57 months (range 4-254 months). 12 cases of progression to vaginal squamocellular cancer were observed (5.8%), with a mean time interval from treatment to progression of 54.6 months (range 4-146 months). The rate of progression was significantly higher in women diagnosed with VaIN3 compared with VaIN2 (15.4% vs. 1.4%, p < 0.0001). Women with HG-VaIN and with previous hysterectomy showed a significantly higher rate of progression to invasive vaginal cancer compared to non-hysterectomised women (16.7% vs. 1.4%, p < 0.0001). A higher risk of progression for women with VaIN3 and for women with previous hysterectomy for cervical HPV-related disease was confirmed by multivariable logistic regression analysis. CONCLUSIONS: A higher rate of progression to vaginal cancer was reported in women diagnosed with VaIN3 on biopsy and in women with previous hysterectomy for HPV-related cervical disease. These patients should be considered at higher risk, thus a long lasting and accurate follow up is recommended. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/27010135; info:eu-repo/semantics/altIdentifier/wos/WOS:000373350100008; volume:5; issue:20; firstpage:818; lastpage:824; numberofpages:7; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; http://hdl.handle.net/11573/944290 |
| Availability: |
http://hdl.handle.net/11573/944290 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.10A12B77 |
| Database: |
BASE |