| Title: |
The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications |
| Authors: |
Zhu, Daoqi; Zeng, Siying; Su, Chao; Li, Jingjun; Xuan, Yiwen; Lin, Yongkai; Xu, Enwu; Fan, Qin |
| Contributors: |
Project of Administration of Traditional Chinese Medicine of Guangdong Province of China; Science and Technology Program of Guangzhou; 2022 "Young Science and Technology Talent Recruitment Project" of Guangzhou Science and Technology Association; Project of General Hospital of Southern Theater Command; National Natural Science Foundation of China; Natural Science Foundation of Guangdong Province of China |
| Source: |
Clinical Epigenetics ; volume 16, issue 1 ; ISSN 1868-7083 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Description: |
DNA methylation is a pivotal epigenetic modification that affects gene expression. Tumor immune microenvironment (TIME) comprises diverse immune cells and stromal components, creating a complex landscape that can either promote or inhibit tumor progression. In the TIME, DNA methylation has been shown to play a critical role in influencing immune cell function and tumor immune evasion. DNA methylation regulates immune cell differentiation, immune responses, and TIME composition Targeting DNA methylation in TIME offers various potential avenues for enhancing immune cytotoxicity and reducing immunosuppression. Recent studies have demonstrated that modification of DNA methylation patterns can promote immune cell infiltration and function. However, challenges persist in understanding the precise mechanisms underlying DNA methylation in the TIME, developing selective epigenetic therapies, and effectively integrating these therapies with other antitumor strategies. In conclusion, DNA methylation of both tumor cells and immune cells interacts with the TIME, and thus affects clinical efficacy. The regulation of DNA methylation within the TIME holds significant promise for the advancement of tumor immunotherapy. Addressing these challenges is crucial for harnessing the full potential of epigenetic interventions to enhance antitumor immune responses and improve patient outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s13148-024-01633-x |
| DOI: |
10.1186/s13148-024-01633-x.pdf |
| DOI: |
10.1186/s13148-024-01633-x/fulltext.html |
| Availability: |
https://doi.org/10.1186/s13148-024-01633-x; https://link.springer.com/content/pdf/10.1186/s13148-024-01633-x.pdf; https://link.springer.com/article/10.1186/s13148-024-01633-x/fulltext.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.10AE33C6 |
| Database: |
BASE |