| Title: |
Global, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023 |
| Authors: |
GBD 2023 Breast Cancer Collaborators; Luca Cegolon; Lisa M. Force; Giulia Zamagni |
| Contributors: |
2023 Breast Cancer Collaborators, Gbd; Cegolon, Luca; Force, Lisa M.; Zamagni, Giulia |
| Publication Year: |
2026 |
| Collection: |
Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| Subject Terms: |
Global Burden of Disease; breast cancer; mortality; indidence; prevalence; DALYs |
| Description: |
Background: Breast cancer is a leading cause of mortality and morbidity among females worldwide. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, we provided an updated comprehensive assessment of the epidemiological trends, disease burden, and risk factors associated with breast cancer globally, regionally, and nationally from 1990 to 2023. Methods: Breast cancer incidence, mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) were estimated by age and sex for 204 countries and territories from 1990 to 2023. Mortality estimates were generated using GBD Cause of Death Ensemble models, leveraging data from population-based cancer registration systems, vital registration systems, and verbal autopsies. Mortality-to-incidence ratios were calculated to derive both mortality and incidence estimates. Prevalence was calculated by combining incidence and modelled survival estimates. YLLs were established by multiplying age-specific deaths with the GBD standard life expectancy at the age of death. YLDs were estimated by applying disability weights to prevalence estimates. The sum of YLLs and YLDs equalled the number of DALYs. Breast cancer burden attributable to seven risk factors was examined through the comparative risk assessment framework. The GBD forecasting framework was used to forecast breast cancer incidence and mortality from 2024 to 2050. Age-standardised rates were calculated for each metric using the GBD 2023 world standard population. Findings: In 2023, there were an estimated 2·30 million (95% uncertainty interval [UI] 2·01 to 2·61) breast cancer incident cases, 764 000 deaths (672 000 to 854 000), and 24·1 million (21·3 to 27·5) DALYs among females globally. In the World Bank low-income group, where a low age-standardised incidence rate (ASIR) was estimated (44·2 per 100 000 person-years [31·2 to 58·4]), the age-standardised mortality rate (ASMR) was the highest (24·1 per 100 000 [16·8 to ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-1-4702-0452-5; 1-4702-0452-5 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41785894; volume:27; issue:3; firstpage:302; lastpage:326; numberofpages:25; journal:THE LANCET ONCOLOGY; https://hdl.handle.net/11368/3127278; https://www.sciencedirect.com/science/article/pii/S1470204525007302?via=ihub |
| DOI: |
10.1016/S1470-2045(25)00730-2 |
| Availability: |
https://hdl.handle.net/11368/3127278; https://doi.org/10.1016/S1470-2045(25)00730-2; https://www.sciencedirect.com/science/article/pii/S1470204525007302?via=ihub |
| Rights: |
info:eu-repo/semantics/closedAccess ; license:Copyright Editore ; license:Digital Rights Management non definito ; license uri:iris.PRI02 ; license uri:iris.PRI00 |
| Accession Number: |
edsbas.110D226D |
| Database: |
BASE |