| Title: |
Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core |
| Authors: |
Ţînţaş, Mihaela-Liliana; Peauger, Ludovic; Alix, Florent; Papamicaël, Cyril; Besson, Thierry; Sopková-de Oliveira Santos, Jana; Gembus, Vincent; Levacher, Vincent |
| Contributors: |
Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA); Institut de Chimie Organique Fine (IRCOF); Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie); Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN); Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN); Normandie Université (NU)-Université Le Havre Normandie (ULH); Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie); Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN); Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN); Normandie Université (NU)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS); VFP Therapies Drugs : Highway to the Brain; Association Française des Enseignants de Chimie Thérapeutique; Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN); Normandie Université (NU)-Normandie Université (NU); ANR-18-EURE-0020,XL Chem,XLChem, Synthesizing our future(2018); ANR-11-LABX-0029,SYNORG,Synthèse Organique : des molécules au vivant(2011); ANR-16-CRNT-0005,Innovation Chimie Carnot,Innovation Chimie Carnot(2016) |
| Source: |
ISSN: 1420-3049 ; Molecules ; https://hal.science/hal-03922046 ; Molecules, 2023, 28 (1), pp.36. ⟨10.3390/molecules28010036⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2023 |
| Collection: |
Normandie Université: HAL |
| Subject Terms: |
Alzheimer's disease; molecular docking; radical scavenger; antioxidant; dual inhibitor; dihydroquinoline; hCLK1; hDYRK1A; Down syndrome; [CHIM.THER]Chemical Sciences/Medicinal Chemistry |
| Description: |
International audience ; The DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase) family of protein kinases is involved in the pathogenesis of several neurodegenerative diseases. Among them, the DYRK1A protein kinase is thought to be implicated in Alzheimer’s disease (AD) and Down syndrome, and as such, has emerged as an appealing therapeutic target. DYRKs are a subset of the CMGC (CDK, MAPKK, GSK3 and CLK) group of kinases. Within this group of kinases, the CDC2-like kinases (CLKs), such as CLK1, are closely related to DYRKs and have also sparked great interest as potential therapeutic targets for AD. Based on inhibitors previously described in the literature (namely TG003 and INDY), we report in this work a new class of dihydroquinolines exhibiting inhibitory activities in the nanomolar range on hDYRK1A and hCLK1. Moreover, there is overwhelming evidence that oxidative stress plays an important role in AD. Pleasingly, the most potent dual kinase inhibitor 1p exhibited antioxidant and radical scavenging properties. Finally, drug-likeness and molecular docking studies of this new class of DYRK1A/CLK1 inhibitors are also discussed in this article. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/molecules28010036 |
| Availability: |
https://hal.science/hal-03922046; https://hal.science/hal-03922046v1/document; https://hal.science/hal-03922046v1/file/molecules-28-00036-v2.pdf; https://doi.org/10.3390/molecules28010036 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.11209588 |
| Database: |
BASE |