| Title: |
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients |
| Authors: |
Burnett, Cassandra E; Okholm, Trine Line Hauge; Tenvooren, Iliana; Marquez, Diana M; Tamaki, Stanley; Sandoval, Priscila Munoz; Willmore, Andrew; Consortium, The UCSF COMET; Patel, Ravi; Abe-Jones, Yumiko; Asthana, Saurabh; Beagle, Alexander; Bhide, Sharvari; Cai, Cathy; Calvo, Maria; Carrillo, Sidney A; Chak, Suzanna; Collins, Zachary; Darmanis, Spyros; Fragiadakis, Gabriela K; Ghale, Rajani; Giberson, Jeremy; Glenn, Pat; Gonzalez, Ana; Hiam-Galvez, Kamir; Jauregui, Alejandra; Ke, Serena; Lea, Tasha; Lee, Deanna; Lota, Raphael; Lupin-Jimenez, Leonard; Nguyen, Viet; Nigam, Nishita; Pierce, Logan; Prasad, Priya; Rao, Arjun; Rashid, Sadeed; Rodriguez, Nicklaus; Samad, Bushra; Shaw, Cole; Sigman, Austin; Sinha, Pratik; Tang, Kevin; Altamirano, Luz Torres; Tumurbaatar, Erden; Upadhyay, Vaibhav; Ward, Alyssa; Wong, Kristine; Ye, Chun Jimmie; Yee, Kimberly; Zhou, Mingyue; Hendrickson, Carolyn M; Kangelaris, Kirsten N; Langelier, Charles R; Krummel, Matthew F; Woodruff, Prescott G; Calfee, Carolyn S; Erle, David J; Ansel, K Mark; Spitzer, Matthew H |
| Source: |
Immunity, vol 55, iss 7 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2022 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3204 Immunology (for-2020); Lung (rcdc); Emerging Infectious Diseases (rcdc); Coronaviruses (rcdc); Infectious Diseases (rcdc); Hematology (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Inflammatory and immune system (hrcs-hc); Infection (hrcs-hc); 3 Good Health and Well Being (sdg); COVID-19 (mesh); Disease Progression (mesh); Humans (mesh); Pneumonia (mesh); SARS-CoV-2 (mesh); UCSF COMET Consortium; COVID-19; disease resolution; immune cell signaling; immune response; recovery; 1107 Immunology (for); Immunology (science-metrix) |
| Time: |
1284 - 1298.e3 |
| Description: |
While studies have elucidated many pathophysiological elements of COVID-19, little is known about immunological changes during COVID-19 resolution. We analyzed immune cells and phosphorylated signaling states at single-cell resolution from longitudinal blood samples of patients hospitalized with COVID-19, pneumonia and/or sepsis, and healthy individuals by mass cytometry. COVID-19 patients showed distinct immune compositions and an early, coordinated, and elevated immune cell signaling profile associated with early hospital discharge. Intra-patient longitudinal analysis revealed changes in myeloid and Tcell frequencies and a reduction in immune cell signaling across cell types that accompanied disease resolution and discharge. These changes, together with increases in regulatory Tcells and reduced signaling in basophils, also accompanied recovery from respiratory failure and were associated with better outcomes at time of admission. Therefore, although patients have heterogeneous immunological baselines and highly variable disease courses, a core immunological trajectory exists that defines recovery from severe SARS-CoV-2 infection. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt7tt8m233; https://escholarship.org/uc/item/7tt8m233; https://escholarship.org/content/qt7tt8m233/qt7tt8m233.pdf |
| DOI: |
10.1016/j.immuni.2022.06.004 |
| Availability: |
https://escholarship.org/uc/item/7tt8m233; https://escholarship.org/content/qt7tt8m233/qt7tt8m233.pdf; https://doi.org/10.1016/j.immuni.2022.06.004 |
| Rights: |
public |
| Accession Number: |
edsbas.11236E29 |
| Database: |
BASE |