| Title: |
Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal |
| Authors: |
Parra, Esteban J.; Mazurek, Andrew; Gignoux, Christopher R.; Sockell, Alexandra; Agostino, Michael; Morris, Andrew P.; Petty, Lauren E.; Hanis, Craig L.; Cox, Nancy J.; Valladares-Salgado, Adan; Below, Jennifer E.; Cruz, Miguel |
| Publisher Information: |
University of Liverpool |
| Publication Year: |
2018 |
| Collection: |
DataCat: The Research Data Catalogue (University of Liverpool) |
| Description: |
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene. |
| Document Type: |
text; dataset |
| Language: |
English |
| Relation: |
Parra, Esteban J., Mazurek, Andrew, Gignoux, Christopher R., Sockell, Alexandra, Agostino, Michael, Morris, Andrew P., Petty, Lauren E., Hanis, Craig L., Cox, Nancy J., Valladares-Salgado, Adan, Below, Jennifer E. and Cruz, Miguel (2018) Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. [Data Collection] |
| Availability: |
https://datacat.liverpool.ac.uk/1890/ |
| Accession Number: |
edsbas.1163218E |
| Database: |
BASE |