| Title: |
Predicting Functional Consequences of Recent Natural Selection in Britain |
| Authors: |
Poyraz, Lin; Colbran, Laura L; Mathieson, Iain |
| Contributors: |
Heyer, Evelyne; National Human Genome Research Institute; National Institute of General Medical Sciences |
| Source: |
Molecular Biology and Evolution ; volume 41, issue 3 ; ISSN 0737-4038 1537-1719 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Ancient DNA can directly reveal the contribution of natural selection to human genomic variation. However, while the analysis of ancient DNA has been successful at identifying genomic signals of selection, inferring the phenotypic consequences of that selection has been more difficult. Most trait-associated variants are noncoding, so we expect that a large proportion of the phenotypic effects of selection will also act through noncoding variation. Since we cannot measure gene expression directly in ancient individuals, we used an approach (Joint-Tissue Imputation [JTI]) developed to predict gene expression from genotype data. We tested for changes in the predicted expression of 17,384 protein coding genes over a time transect of 4,500 years using 91 present-day and 616 ancient individuals from Britain. We identified 28 genes at seven genomic loci with significant (false discovery rate [FDR] < 0.05) changes in predicted expression levels in this time period. We compared the results from our transcriptome-wide scan to a genome-wide scan based on estimating per-single nucleotide polymorphism (SNP) selection coefficients from time series data. At five previously identified loci, our approach allowed us to highlight small numbers of genes with evidence for significant shifts in expression from peaks that in some cases span tens of genes. At two novel loci (SLC44A5 and NUP85), we identify selection on gene expression not captured by scans based on genomic signatures of selection. Finally, we show how classical selection statistics (iHS and SDS) can be combined with JTI models to incorporate functional information into scans that use present-day data alone. These results demonstrate the potential of this type of information to explore both the causes and consequences of natural selection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/molbev/msae053 |
| DOI: |
10.1093/molbev/msae053/56922987/msae053.pdf |
| Availability: |
https://doi.org/10.1093/molbev/msae053; https://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msae053/56922987/msae053.pdf; https://academic.oup.com/mbe/article-pdf/41/3/msae053/57087513/msae053.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1193C87E |
| Database: |
BASE |