| Title: |
Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones |
| Authors: |
Beer, Philip A.; Jones, Amy V.; Bench, Anthony J.; Goday‐Fernandez, Andrea; Boyd, Elaine M.; Vaghela, Krishna J.; Erber, Wendy N.; Odeh, Bassam; Wright, Christine; McMullin, Mary Frances; Cullis, Jonathan; Huntly, Brian J. P.; Harrison, Claire N.; Cross, Nicholas C. P.; Green, Anthony R. |
| Source: |
British Journal of Haematology ; volume 144, issue 6, page 904-908 ; ISSN 0007-1048 1365-2141 |
| Publisher Information: |
Wiley |
| Publication Year: |
2009 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X‐chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1365-2141.2008.07560.x |
| Availability: |
https://doi.org/10.1111/j.1365-2141.2008.07560.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2141.2008.07560.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2141.2008.07560.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.119734DA |
| Database: |
BASE |