| Title: |
mRNA expression quantitative trait loci used in the manuscript titled: MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality |
| Authors: |
eQTLGen Consortium; van der Graaf, Adriaan |
| Contributors: |
van der Graaf, Adriaan; Warmerdam, Robert; Auwerx, Chiara; eQTLGen Consortium; Võsa, Urmo; Borges, Maria Carolina; Franke, Lude; Kutalik, Zoltán |
| Publisher Information: |
Zenodo |
| Publication Year: |
2025 |
| Collection: |
Zenodo |
| Subject Terms: |
eQTL |
| Description: |
eQTLGen Data for MR-link-2This repository contains 54 Parquet files generated by the eQTLGen Consortium. These datasets were used in the [MR-link-2 paper]() to identify the correct direction of causality.---## Important Disclaimer- **These data are provided for reproducing the results of the MR-link-2 paper.**- There is an **upcoming publication** from the eQTLGen Consortium that will feature **larger sample sizes** and **additional gene expression phenotypes**. If you require more comprehensive datasets, please refer to the forthcoming publication once it is available.---## Files Overview- **Number of files:** 54 - **Format:** Parquet - **Content:** Cell-type marker gene eQTL data generated by the eQTLGen Consortium - **Harmonization:** Each file has been harmonized to the UK10K genotype reference and is in b37 ---## Data FormatThe Parquet files follow the **GWAS format specification**, which also makes them compatible with the MR-link-2 method. The schema of each file is as follows:```plaintextchromosome | stringbase_pair_location | uint64effect_allele | stringother_allele | stringbeta | float64standard_error | float64effect_allele_frequency | float64p_value | float64variant_id | stringrsid | stringn | uint64```**Field Descriptions:**- **chromosome**: The chromosome on which the variant is located (e.g., "1", "2", "X"). - **base_pair_location**: The base pair position of the variant on the chromosome. - **effect_allele**: The allele for which the effect size (`beta`) is reported. - **other_allele**: The non-effect allele. - **beta**: The estimated effect size of the effect allele on the gene expression. - **standard_error**: The standard error of the effect size estimate. - **effect_allele_frequency**: The frequency of the effect allele in the reference dataset (UK10K). - **p_value**: The p-value for the association. - **variant_id**: A unique identifier for the variant (often in the format `chr:pos:ref:alt`). - **rsid**: The dbSNP rs identifier (if available). - **n**: The sample size for the specific ... |
| Document Type: |
dataset |
| Language: |
English |
| Relation: |
https://zenodo.org/records/14982208; oai:zenodo.org:14982208; https://doi.org/10.5281/zenodo.14982208 |
| DOI: |
10.5281/zenodo.14982208 |
| Availability: |
https://doi.org/10.5281/zenodo.14982208; https://zenodo.org/records/14982208 |
| Rights: |
Creative Commons Attribution 4.0 International ; cc-by-4.0 ; https://creativecommons.org/licenses/by/4.0/legalcode |
| Accession Number: |
edsbas.11BA2599 |
| Database: |
BASE |