| Title: |
Early psoriatic arthritis: The clinical spectrum |
| Authors: |
Scarpa R; Cuocolo A; Peluso R; Atteno M; Gisonni P; Iervolino S; Di Minno MND; Nicolai E; Salvatore M; del Puente A |
| Source: |
Journal of rheumatology (2008). ; info:cnr-pdr/source/autori:Scarpa R; Cuocolo A; Peluso R; Atteno M; Gisonni P; Iervolino S; Di Minno MND; Nicolai E; Salvatore M; del Puente A/titolo:Early psoriatic arthritis: The clinical spectrum/doi:/rivista:Journal of rheumatology/anno:2008/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| Publisher Information: |
Journal of Rheumatology Pub. Co., Toronto , Canada |
| Publication Year: |
2008 |
| Collection: |
PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Description: |
Objective. The aim of this study was to characterize the clinical pattern of early psoriatic arthritis (EPA). Methods. We studied 47 consecutive patients: 29 patients had definite psoriatic arthritis and 18 had the "sine psoriasis" subset. Inclusion criteria were an articular and/or an entheseal involvement lasting no more than 12 weeks and the exclusive use, before enrollment, of non-steroid anti-inflammatory drugs to control articular symptoms. All patients underwent clinical examination, blood tests, total body bone scintigraphy, articular ultrasonography and radiography of joints and/or entheses clinically involved. Results. On the basis of clinical examination, EPA was an oligo-enthesoarthritis in over 75% of the patients studied. In contrast, the number of joints and/or entheses showing increased tracer uptake at bone scintigraphy was 3 times greater as compared to clinical evidence (p < 0.001). Articular ultrasonography confirmed the inflammatory involvement of synovium and/or entheses in all articular sites active at bone scintigraphy, but silent at clinical examination. In addition, 7 patients showed the occurrence of joint and/or entheseal erosions at standard radiography. Conclusion. The results of this study demonstrate that bone scintigraphy yields a more accurate evaluation of entheso-articular involvement and distribution in patients with EPA. In addition, our results suggest that clinical oligo-enthesoarthritic presentation of EPA might represent in most cases a polyarticular condition, which is at an increased risk of clinical progression. These findings have a significant impact on the clinical decision making process in EPA patients. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:cnr-pdr/author/idpersonaleesterno:2643/CUOCOLO/ALBERTO; http://www.cnr.it/prodotto/i/179943; https://publications.cnr.it/doc/179943 |
| Availability: |
http://www.cnr.it/prodotto/i/179943; https://publications.cnr.it/doc/179943 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.11CE3DBD |
| Database: |
BASE |