Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
| Title: | Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC) |
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| Authors: | Aliberti S; Ringshausen FC; Dhar R; Haworth CS; Loebinger MR; Dimakou K; Crichton ML; De Soyza A; Vendrell M; Burgel P-R; McDonnell M; Skrgat S; Maiz Carro L; de Roux A; Sibila O; Bossios A; van der Eerden M; Kauppi P; Wilson R; Milenkovic B; Menendez R; Murris M; Borekci S; Munteanu O; Obradovic D; Nowinski A; Amorim A; Torres A; Lorent N; Van Braeckel E; Altenburg J; Shoemark A; Shteinberg M; Boersma W; Goeminne PC; Elborn JS; Hill AT; Welte T; Blasi F; Polverino E; Chalmers JD |
| Source: | European Respiratory Journal, 1 April 2024 |
| Publisher Information: | European Respiratory Society |
| Publication Year: | 2024 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | Copyright ©The authors 2024. BACKGROUND: A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the European Bronchiectasis Registry (EMBARC), we tested whether sputum colour would be associated with disease severity and clinical outcomes. METHODS: We used a prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits. Key outcomes were frequency of exacerbations, hospitalisations for severe exacerbations and mortality during up to 5-year follow-up. RESULTS: 13 484 patients were included in the analysis. More purulent sputum was associated with lower forced expiratory volume in 1 s (FEV1), worse quality of life, greater bacterial infection and a higher bronchiectasis severity index. Sputum colour was strongly associated with the risk of future exacerbations during follow-up. Compared to patients with mucoid sputum (reference group), patients with mucopurulent sputum experienced significantly more exacerbations (incident rate ratio (IRR) 1.29, 95% CI 1.22-1.38; p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/298252; https://eprints.ncl.ac.uk/fulltext.aspx?url=298252/DE8EBEB2-AB84-4AC1-BCD3-AC3A5960CE78.pdf&pub_id=298252 |
| Availability: | https://eprints.ncl.ac.uk/298252 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: | edsbas.123E5FC |
| Database: | BASE |