| Title: |
Lung function in men with and without HIV |
| Authors: |
Kunisaki, Ken M.; Nouraie, Mehdi; Jensen, Robert L.; Chang, Dong; D'Souza, Gypsyamber; Fitzpatrick, Meghan E.; McCormack, Meredith C.; Stosor, Valentina; Morris, Alison |
| Source: |
AIDS ; volume 34, issue 8, page 1227-1235 ; ISSN 0269-9370 1473-5571 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2020 |
| Description: |
Objectives: Initial studies suggest HIV-positive persons may be at increased risk for chronic lung diseases such as chronic obstructive pulmonary disease, but have commonly relied on single-center designs, lacked HIV-negative controls, or assessed lung function with only spirometry. We tested differences in spirometry and single-breath diffusing capacity for carbon monoxide (DL CO ) in persons with and without HIV. Design: Cross-sectional, observational study. Methods: Participants were enrolled from the Multicenter AIDS Cohort Study, a longitudinal cohort study of men who have sex with men (both HIV-positive and HIV-negative) at four sites in the United States. Standardized spirometry and DL CO testing were performed in all eligible, consenting participants at routine study visits. We tested associations between HIV status and spirometry and DL CO results, using linear and logistic regression. Results: Among 1067 men, median age was 57 years, prevalence of current marijuana (30%), and cigarette (24%) use was high, and another 45% were former cigarette smokers. Median forced expiratory volume in 1 s was 97% of predicted normal and DL CO was 85% of predicted normal. HIV-positive persons demonstrated no statistical difference in forced expiratory volume in 1 s compared with HIV-negative persons, but had worse DL CO (adjusted difference −2.6% of predicted; 95% confidence interval: −4.7 to −0.6%) and a higher risk of DL CO impairment (odds ratio for DL CO < 60% of predicted 2.97; 95% confidence interval: 1.36–6.47). Lower DL CO was associated with lower nadir CD4 + cell counts. Conclusion: HIV-positive men are at increased risk of abnormal gas exchange, indicated by low DL CO , compared with men without HIV. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/qad.0000000000002526 |
| DOI: |
10.1097/QAD.0000000000002526 |
| Availability: |
https://doi.org/10.1097/qad.0000000000002526; https://journals.lww.com/10.1097/QAD.0000000000002526 |
| Accession Number: |
edsbas.125785C |
| Database: |
BASE |