| Title: |
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials |
| Authors: |
Teerlink, John R.; Diaz, Rafael; Felker, G. Michael; McMurray, John J.V.; Metra, Marco; Solomon, Scott D.; Adams, Kirkwood F.; Anand, Inder; Arias‐Mendoza, Alexandra; Biering‐Sørensen, Tor; Böhm, Michael; Bonderman, Diana; Cleland, John G.F.; Corbalan, Ramon; Crespo‐Leiro, Maria G.; Dahlström, Ulf; Echeverria Correa, Luis E.; Fang, James C.; Filippatos, Gerasimos; Fonseca, Cândida; Goncalvesova, Eva; Goudev, Assen R.; Howlett, Jonathan G.; Lanfear, David E.; Lund, Mayanna; Macdonald, Peter; Mareev, Vyacheslav; Momomura, Shin‐ichi; O'Meara, Eileen; Parkhomenko, Alexander; Ponikowski, Piotr; Ramires, Felix J. A.; Serpytis, Pranas; Sliwa, Karen; Spinar, Jindrich; Suter, Thomas M.; Tomcsanyi, Janos; Vandekerckhove, Hans; Vinereanu, Dragos; Voors, Adriaan A.; Yilmaz, Mehmet B.; Zannad, Faiez; Sharpsten, Lucie; Legg, Jason C.; Abbasi, Siddique A.; Varin, Claire; Malik, Fady I.; Kurtz, Christopher E.; Besada, Diego Alejandro; Majul, Claudio Rodolfo; Bruno, Marco Raul Litvak; Sassone, Sonia; Avaca, Horacio Alberto; Rasmussen, Mariela; Aiub, Jorge Roberto; Hominal, Miguel Angel; Perna, Eduardo; Duran, Ruben Omar Garcia; Schiavi, Lilia; Marquez, Lilia Luz Lobo; Vilamajo, Oscar Alberto Gomez; Mackinnon, Ignacio; Fuente, Ricardo Alfonso Leon; Montana, Oscar Romano; Novaretto, Leonardo; Guerrero, Rodolfo Andres Ahuad; Brasca, Daniela Garcia; Prado, Aldo; Garrido, Marcelo Alejandro; Luquez, Hugo; Martinez, Diego Felipe; Nicolosi, Liliana; Parody, Maria Leonor; Zaidman, Cesar; Berra, Fernando Colombo; Ibañez, Julio; Zapata, Gerardo; Caccavo, Alberto; Colque, Roberto; Diez, Mirta; Poy, Carlos; Salomone, Oscar Alejandro; Vogel, Daniel; Bordonava, Anselmo Paulino; Fernandez, Alberto; French, John; Atherton, John; Hamilton, Andrew; Begg, Alistair; Abhayaratna, Walter; Judkins, Christopher; De Pasquale, Carmine; McKenzie, Scott; Amerena, John; Szto, Gregory; Kearney, Leighton; Zimmet, Hendrik; Sverdlov, Aaron; Beltrame, John; Korczyk, Dariusz; Sindone, Andrew; Moertl, Deddo; Huber, Kurt; Huelsmann, Martin; Ablasser, Klemens; Ebner, Christian; Siostrzonek, Peter; Drexel, Heinz; Poelzl, Gerhard; Dujardin, Karl; Dupont, Matthias; Buysschaert, Ian; Lancellotti, Patrizio; Droogne, Walter; Chouchane, Iman; Silveira, Fabio; Rassi, Salvador; Reis, Gilmar; Filho, Pedro Pimentel; Simoes, Marcus Vinicius; Braga, Joao Carlos; Giorgeto, Flavio Eduardo; Ferraz, Almir; Jaeger, Cristiano Pederneiras; Saraiva, Jose Francisco; Tognon, Alexandre; Cardoso, Juliano; Greco, Oswaldo; Paiva, Maria Sanali; Paolino, Bruno; Filho, Otavio Coelho; Maia, Lilia Nigro; Silva, Rodrigo; Canesin, Manoel; Rossi, Paulo Roberto Ferreira; Fortes, Jose Augusto Ribas; Cerci, Rodrigo Julio; Manenti, Euler Roberto Fernandes; Leaes, Paulo Ernesto; Silva Neto, Luis Beck; Souza, Weimar Kunz Barroso; Bacal, Fernando; Chaves, Renato; Ramires, Felix; Vidotti, Maria Helena; Barros e Silva, Pedro Gabriel Melo; Piegas, Leopoldo Soares; Todorov, Georgi; Tzekova, Maria; Goudev, Assen; Mincheva, Valentina; Vasilev, Ivaylo; Tisheva‐ Gospodinova, Snezhanka; Petrov, Ivo; Postadzhiyan, Arman; Velikov, Chavdar; Dimov, Bojidar; Constance, Christian; Phaneuf, Denis‐Carl; Mielniczuk, Lisa; Pandey, A Shekhar; Senaratne, Manohara; Zieroth, Shelley; Savard, Daniel; Stewart, Robert; Huynh, Thao; Giannetti, Nadia; Moe, Gordon; Bourgeois, Ronald; Ezekowitz, Justin; Hartleib, Michael; Sussex, Bruce; Babapulle, Mohan; Chehayeb, Raja; Gaudet, Daniel; McKelvie, Robert; Nguyen, Viviane; Roth, Sherryn; Gupta, Milan; Pesant, Yves; Rupka, Dennis; Bhargava, Rakesh; Costa‐Vitali, Atilio; Proulx, Guy; Vega, Mario; Potthoff, Sergio; Cid, Maria Cristina Schnettler; Sepulveda, Alex Mauricio Villablanca; Zanetti, Fernando Tomas Lanas; Gajardo, Victor Areli Saavedra; Kindel, Carlos Conejeros; Jofre, Christian Paolo Pincetti; Segarra, Jorge Leonardo Cobos; Venegas, Manuel Eduardo Rodriguez; Hidalgo, Mario Yanez; Jalaf, Margarita Gertrudis Vejar; Li, Weimin; Zhang, Jinguo; Fu, Xin; Zhang, Xuelian; Li, Dongye; Wang, Zhifang; Qu, Yanling; Zheng, Zhe; Tang, Huifang; Yang, Ping; Zhang, Yuhui; Zheng, Yang; Mi, Yafei; Huang, He; Bu, Peili; Chen, Guoqin; Chen, Jiyan; Han, Yajun; Li, Zhangquan; Ma, Shumei; Yang, Xuming; Yuan, Zuyi; Dong, Yugang; Li, Zhaoping; Mahemuti, Ailiman; Niu, Wentang; Yang, Zhenyu; Zhang, Yuqing; Sun, Yuemin; Wu, Weiheng; Liu, Feng; Yan, Jing; Li, Yinjun; Wang, Yi; Zhang, Shouyan; Zhou, Changyong; Cui, Hanbin; Li, Jianjun; Li, Tianfa; Han, Qinghua; Wei, Yu; Correa, Luis Eduardo Echeverria; Mendoza, Jose Luis Accini; Jattin, Fernando Manzur; Osorio, Wilder Castaño; Luengas, Carlos Alberto; Arroyo, Julian Alonso Coronel; Corredor, Miguel Alfredo Moncada; Giraldo, Clara Ines Saldarriaga; Lopez, Rodrigo Botero; Salazar, Dora Ines Molina; Triana, Miguel Urina; Lopez, Luis Horacio Atehortua; Rojas, Pastor Olaya; Pelaez, Sebastian Velez; Pareja, Monica Lopez; Bonfanti, Alberto Cadena; Polasek, Rostislav; Monhart, Zdenek; Sochor, Karel; Motovska, Zuzana; Belohlavek, Jan; Busak, Ladislav; Krupicka, Jiri; Tyl, Petr; Jerabek, Ondrej; Podpera, Ivo; Skrobakova, Janka; Peterka, Karel; Spacek, Rudolf; Cech, Vladimir; Kellnerova, Ivana; Nechvatal, Libor; Pozdisek, Zbynek; Houra, Marek; Kryza, Radim; Machova, Vilma; Cepelak, Michal; Stepek, David; Zeman, Kamil; Klimsa, Zdenek; Koleckar, Pavel; Schee, Alexandr; Spinarova, Lenka; Coufal, Zdenek; Jeppesen, Jorgen; Vraa, Soren; Wiggers, Henrik; Nyvad, Ole; Nielsen, Tonny; Kaiser‐Nielsen, Peter; Videbaek, Lars; Galinier, Michel; Lefebvre, Jean‐Marie; Tartiere, Jean‐Michel; De Geeter, Guillaume; Roubille, Francois; Ricci, Jean Etienne; Salvat, Muriel; Gueffet, Jean‐Pierre; Decoulx, Eric; Berdague, Philippe; Jondeau, Guillaume; Ovize, Michel; Groote, Pascal De; Donal, Erwan; Isnard, Richard; Sabatier, Rémi; Trochu, Jean Noel; Damy, Thibaud; Georges, Jean‐Louis; Rosamel, Yann; Picard, François; Aboyans, Victor; Laperche, Thierry; Mitrovic, Veselin; Taggeselle, Jens; Störk, Stefan; Ebelt, Henning; Genth‐Zotz, Sabine; Rassaf, Tienush; Duengen, Hans‐Dirk; Mittag, Marcus; Menck, Niels; Zeymer, Uwe; Haehling, Stephan; Boehm, Michael; Frankenstein, Lutz; Killat, Holger; Bourhaial, Hakima; Beug, Daniel; Horacek, Thomas; Pfister, Roman; Sandri, Marcus; Westenfeld, Ralf; Kadel, Christoph; Karvounis, Haralambos; Patsilinakos, Sotirios; Mantas, Ioannis; Karavidas, Apostolos; Giamouzis, Grigorios; Tsioufis, Konstantinos; Naka, Katerina; Tziakas, Dimitrios; Parissis, John; Styliadis, Ioannis; Barbetseas, Ioannis; Manolis, Athanasios; Kochiadakis, George; Herczeg, Bela; Nagy, Laszlo; Nyolczas, Noemi; Toth, Kalman; Merkely, Bela; Laszlo, Zoltan; Mark, Laszlo; Szakal, Imre; Papp, Andras; Bezzegh, Katalin; Lakatos, Ferenc; Hajko, Erik; Papp, Aniko; Forster, Tamas; Lupkovics, Geza; Mohacsi, Attila; Salamon, Csaba; Aradi, Daniel; Andreka, Peter; Szasz, Gyula; Zilahi, Zsolt; Kazinczy, Rita; Margonato, Alberto; Agostoni, Piergiuseppe; Fucili, Alessandro; Piovaccari, Giancarlo; Senni, Michele; Carluccio, Erberto; Bilato, Claudio; Frigerio, Maria; Indolfi, Ciro; Sinagra, Gianfranco; Brunetti, Natale Daniele; Perna, Gianpiero; Pini, Daniela; Volterrani, Maurizio; Leonardi, Sergio; Mortara, Andrea; Friz, Hernan Emilio Francisco Polo; Rossini, Roberta; Tocchetti, Carlo Gabriele; Vincenzi, Antonella; Cavallini, Claudio; Floresta, Agata Marina; Zaca, Valerio; Giudici, Vittorio; Villani, Giovanni Quinto; Higashino, Yorihiko; Oishi, Shogo; Wada, Atsuyuki; Fukuzawa, Shigeru; Onoue, Kenji; Koike, Akihiro; Koizumi, Tomomi; Masuda, Seigo; Mitsuo, Kazuhisa; Takahashi, Natsuki; Takenaka, Takashi; Tanabe, Jun; Watanabe, Naoki; Yoshida, Takeshi; Amano, Tetsuya; Ishikawa, Masahiro; Kida, Keisuke; Kubota, Toru; Nakamura, Kentaro; Sakamoto, Tomohiro; Shimomura, Mitsuhiro; Yuge, Masaru; Doi, Masayuki; Domae, Hiroshi; Ebato, Mio; Fujii, Kenshi; Fujiwara, Wakaya; Gohara, Seiichiro; Hata, Yoshiki; Kanda, Junji; Kitaoka, Hiroaki; Matsumoto, Takashi; Michishita, Ichiro; Miura, Shinichiro; Miyazaki, Tetsuro; Nakamura, Akihiro; Ogawa, Tomohiro; Okumura, Takahiro; Okumura, Yasuo; Sakai, Tetsuo; Sato, Yukihito; Shimizu, Wataru; Sugino, Hiroshi; Suzuki, Masahiro; Takagi, Atsutoshi; Takaishi, Hiroshi; Tanaka, Takahiro; Terasaki, Toshiro; Tsujimoto, Mitsuru; Ueda, Yasunori; Ujino, Keiji; Usui, Makoto; Yamamoto, Mitsutaka; Yoshikawa, Masaki; Ando, Kenji; Asakura, Masanori; Asano, Hiroshi; Fujii, Shigeru; Hara, Hisao; Inomata, Takayuki; Isshiki, Takaaki; Kadokami, Toshiaki; Kai, Hisashi; Kasai, Toshio; Kawamitsu, Katsunori; Kawasaki, Tomohiro; Koga, Tokushi; Komiyama, Nobuyuki; Maejima, Yasuhiro; Manita, Mamoru; Miyamoto, Nobuhide; Node, Koichi; Numaguchi, Kotaro; Sakata, Yasushi; Serikawa, Takeshi; Takama, Noriaki; Tatebe, Shunsuke; Ueno, Hideki; Hidaka, Takayuki; Hiroi, Shitoshi; Iseki, Harukazu; Ito, Hiroshi; Kajinami, Kouji; Kawakami, Hideo; Momiyama, Yukihiko; Mori, Masuki; Morita, Yukiko; Okishige, Kaoru; Sakagami, Satoru; Takeishi, Yasuchika; Terasawa, Akihiro; Utsu, Noriaki; Badariene, Jolita; Celutkiene, Jelena; Slapikas, Rimvydas; Jarasuniene, Dalia; Castillo, Armando Garcia; De los Rios Ibarra, Manuel Odin; Lopez, Gabriel Arturo Ramos; Llamas, Edmundo Alfredo Bayram; Esperon, Guillermo Antonio Llamas; Vazquez, Eduardo Salcido; Gonzalez, Ricardo Garcia; Leon, Jose Luis Arenas; Gonzalez, Salvador Leon; Mendoza, Maria Alexandra Arias; Rodriguez, Alicia Contreras; Machado, Gustavo Francisco Mendez; Salazar, Melchor Alpizar; Ruiz, Alberto Esteban Bazzoni; Flores, Ana Maria De Leon; Carrasco, Jose Alfredo Pagola; Araiza, Raul Reyes; Römer, Tjeerd; Remmen, Johannes; Van Eck, Jacob; Elvan, Arif; Smilde, Tom; Voors, Adriaan; Wal, Ruud; Schaap, Jeroen; Sluis, Aize; Linssen, Gerardus; Magro, Michael; Willems, Frank; Hal, John; Zwaan, Coenraad; Beelen, Driek; Boswijk, Dirk; Hermans, Walter; Van Kesteren, Henricus; Scott, Russell; Hart, Hamish; Lund, Marianne; Szczasny, Marcin; Blicharski, Tomasz; Kafara, Mariusz; Stankiewicz, Anna; Skonieczny, Grzegorz; Zabowka, Maciej; Kania, Grzegorz; Kopaczewski, Jerzy; Pawlowicz, Lidia; Spyra, Janusz; Wlodarczyk, Aleksander; Sciborski, Ryszard; Balsam, Pawel; Drozdz, Jaroslaw; Sobkowicz, Bozena; Konieczynska, Malgorzata; Lelonek, Malgorzata; Bednarkiewicz, Zbigniew; Trebacz, Jaroslaw; Jankowski, Piotr; Sidor, Mateusz; Berkowski, Piotr; Chmielak, Zbigniew; Lenartowska, Lucyna; Nessler, Jadwiga; Straburzynska‐Migaj, Ewa; Kalarus, Zbigniew; Kowalski, Robert; Kalecinska‐Krystkiewicz, Ewa; Gola, Zbigniew; Pijanowski, Zbigniew; Wozakowska‐Kaplon, Beata; Cymerman, Krzysztof; Rynkiewicz, Andrzej; Miekus, Pawel; Monteiro, Pedro; Sarmento, Pedro Morais; Almeida, Filipa; Duarte, Tatiana; Fonseca, Candida; Oliveira, Luis; Santos, Luis; Brito, Dulce; Stanciulescu, Gabriela; Spiridon, Marilena Renata; Militaru, Constantin; Podoleanu, Cristian Gheorghe; Zdrenghea, Dumitru; Popescu, Mircea Ioachim; Macarie, Cezar‐Eugen; Giuca, Alina; Mitu, Florin; Voicu, Olga‐Cristina; Dorobantu, Maria; Lighezan, Daniel; Stamate, Sorin; Bykov, Alexander; Kobalava, Zhanna; Zrazhevskiy, Konstantin; Semenova, Irina; Vishnevsky, Alexander; Shutemova, Elena; Tereschenko, Sergey; Shvarts, Yury; Barbarash, Olga; Lukyanov, Yury; Voevoda, Mikhail; Dovgolis, Svetlana; Dronov, Dmitry; Goloshchekin, Boris; Sitnikova, Maria; Ezhov, Marat; Tarasov, Nikolay; Kotelnikov, Mikhail; Kostenko, Viktor; Solovev, Oleg; Goncharov, Ivan; Myasnikov, Roman; Rafalskiy, Vladimir; Ryabov, Vyacheslav; Kosmacheva, Elena; Motylev, Igor; Nosov, Vladimir; Osipova, Irina; Salukhov, Vladimir; Belenkiy, Dmitriy; Bolshakova, Olga; Pimenov, Leonid; Shilkina, Nataliya; Kulibaba, Elena; Repin, Alexey; Timofeev, Alexander; Mitrokhin, Vladislav; Sherenkov, Alexander; Arbolishvili, Georgy; Antalik, Lubomir; Dzupina, Andrej; Fulop, Peter; Majercak, Ivan; Gonsorcik, Jozef; Vinanska, Daniela; Lenner, Egon; Lukacova, Jana; Margoczy, Roman; Smik, Rudolf; Stevlik, Jan; Uhliar, Rudolf; Burgess, Lesley; Badat, Aysha; Klug, Eric; Van Zyl, Louis; Abelson, Mark; Moodley, Rajendran; Tsabedze, Nqoba; Fourie, Nyda; Bonet, Luis Almenar; Prado, Jose Maria Arizon; Oliveira Soares, Manue Martinez‐Selles D; Villota, Julio Eduardo Nuñez; Leiro, Maria Generosa Crespo; Juanatey, Jose Ramon Gonzalez; Figal, Domingo Andres Pascual; Palomas, Juan Luis Bonilla; Perez, Sonia Mirabet; Jimenez, Juan Francisco Delgado; Padron, Antonio Lara; Diaz, Victor Alfonso Jimenez; Cubero, Javier Segovia; Paya, Vicente Eduardo Climent; Mayoral, Alejandro Recio; Fuente Galan, Luis; Doblas, Juan Jose Gomez; Freire, Ramon Bover; Peiro, Maria Teresa Blasco; Molina, Beatriz Diaz; Martinez, Laura Jordan; Vilchez, Francisco Gonzalez; Boman, Kurt; Karlstrom, Patric; Berglund, Stefan; Szabo, Barna; Peterson, Magnus; Wodlin, Peter; Lindholm, Carl‐Johan; Moccetti, Tiziano; Mueller, Christian; Suter, Thomas; Hullin, Roger; Meyer, Philippe; Noll, Georg; Yigit, Zerrin; Turgut, Okan Onur; Bekar, Lutfu; Sahin, Tayfun; Koldas, Zehra Lale; Celik, Ahmet; Cavusoglu, Yuksel; Demir, Mesut; Onrat, Ersel; Duzenli, Mehmet; Cosansu, Kahraman; Muderrisoglu, Ibrahim Haldun; Tuncer, Mustafa; Badak, Ozer; Nalbantgil, Sanem; Kirma, Cevat; Okuyan, Ertugrul; Guray, Umit; Prokhorov, Oleksandr; Karpenko, Oleksandr; Vakaliuk, Igor; Yagensky, Andriy; Kracz, Igor; Stanislavchuk, Mykola; Kulynych, Oleksii; Rishko, Mykola; Stets, Roman; Tseluyko, Vira; Mishchenko, Larysa; Rudenko, Leonid; Rudyk, Iurii; Alieksieieva, Liudmyla; Korzh, Oleksii; Mostovoy, Yuriy; Parkhomenko, Oleksandr; Rasputina, Lesya; Voronkov, Leonid; Lymar, Yurii; Vasilyeva, Larysa; Keeling, Philip; Barr, Craig; Wong, Kenneth; Price, Dallas; Skaria, Binoy; Clark, Andrew; Chandrasekaran, Badrinathan; Trevelyan, Jasper; Gordon, Brian; Donnelly, Patrick; Glover, Jason; Ryding, Alisdair; Weir, Robin; Lang, Chim; Roy, Debashis; Adhya, Shaumik; Clifford, Piers; Ludman, Andrew; Kalra, Paul; Lynch, Mary; Mahmood, Shahid; Al Mohammad, Abdallah; Asubiaro, Joshua; Elmahi, Einas; Muthumala, Amal; Taylor, Justin; Gupta, Dinesh; Nadar, Venkatesh; Henderson, David; Zolty, Ronald; Sauer, Andrew; Adams, Kirkwood; Chandra, Lokesh; Jaffrani, Naseem; Grewal, Gurinder; Mancini, Donna; McLean, Dalton; Vasallo, Javier; Gottlieb, Stephen; Joseph, Susan; Barua, Rajat; Gorodeski, Eiran; Mouhaffel, Asad; Chung, Eugene; Desai, Pratik; Portnay, Edward; Rama, Bhola; Shandling, Adrian; Stahl, Llyod; Heilman, Karl; Jacob, Binu; Londono, Juan; Almousalli, Omar; Ashcom, Thomas; Bauerlein, Eugene Joseph; Koo, Charles; McGrew, Frank; Rajagopalan, Navin; Robinson, Shawn; Schultz, David; Starling, Randall; Ambardekar, Amrut; Bhagwat, Ravi; Boehmer, John; Bouza, Manuel; Farris, Neil; Feitell, Scott; Ganji, Jagadeesh; Geltman, Edward; Javier, Julian; Morrow, John Andrew; Pianko, Leonard; Smart, Frank; Adler, Alexander; Brinkley, Douglas; Cardona, Jose; Coletti, Andrew; Harris, John; Hunter, Vernon; Krantz, Mori; Lang, Christopher; Lovell, Charles; Murray, David; Pillutla, Priya; Shah, Amit; Bogaev, Roberta; Dauber, Ira; Franchi, Francesco; Fremont, Richard; Hart, Terence; Hattler, Brack; Janik, Matthew; Khalife, Wissam; Malhotra, Sanjay; Mamdani, Shafiq; Nelson, William; Orgera, Marisa; Ortiz, Aurelio; Rahko, Peter; Rennyson, Stephen; Shin, Jooyoung; Tsao, Lana; Uretsky, Barry; Wahid, Faisal; Wilkett, Matt; Amanullah, Aman; Baker, Mathue; Berk, Martin; Boccalandro, Fernando; Cruz, Kimberly; Doyle, Timothy; Gianfagna, Robert; Jones, Alonzo; King, Anthony; Lepor, Norman; Martinez‐Castrillon, Melvin; Pham, Michael; Radin, Michael; Radojevic, Joseph; Ramanathan, Kodangudi; Schmalfuss, Carsten; Schnitzler, Robert; Shah, Keyur; Takata, Theodore; Bertolet, Barry; Bostick, Brian; Civitello, Andrew; Collins, John; Dib, Nabil; Fang, James; Gilmore, Richard; Gray, Wayne; Grazette, Luanda; Haddad, Tariq; Hearne, Steven; Janmohamed, Munir; Katz, Richard; Kazemi, Navid; Llerena, Sara; Lohr, Nicole; Marzouka, George; Mignone, John; Ooi, Henry; Paszczuk, Anna; Pickett, Christopher; Sampognaro, Gregory; Sawyer, Douglas; Shayani, Steven; Treasure, Charles; Vaz, Garth; Vijay, Nampalli; Williams, Celeste; Yeoman, Gary; Zhang, Lily; Aaronson, Keith; Abo‐Auda, Wael; Alharethi, Rami; Anderson, William; Ariani, Mehrdad; Banerji, Sourin; Baweja, Paramdeep; Carson, Peter; Eberly, Arthur; Elliott, James; Fernando, Ronald; Fisher, Daniel; Forman, Steven; Gabriel, George; Gogia, Harinder; Hametz, Craig; Houston, Brian; Ibrahim, Hassan; Jadbabaie, Farid; Kassiotis, Christos; Krishnamoorthy, Arun; Kwan, Michael; Lupovitch, Steven; Macias, Leonardo; Malik, Adnan; Martinez, Luis; Miyamoto, Michael; Mody, Freny; Patel, Devesh; Peart, Brenda; Pisani, Barbara; Ramos, Mark; Rivero, Mariel; Shah, Anil; Sharma, Mukesh; Sichrovsky, Tina; Simon, Marc; Singh, Deovrat; Tallet, Julio; Vaccari, Christopher; Villoch, Mario; Wheeler, Matthew; Yousuf, Kabir; Abadier, Rafik; Abdullah, Shuaib; Arora, Raveen; Aslam, Shamaila; Buynak, Robert; Chang, David; Contreras, Johanna; Halpern, Stephen; Handel, Franklin; Heitner, John; Herzog, William; Jackson, Bruce; Kao, John; Kondo, Nicholas; Koren, Michael; LeWinter, Martin; Martindale, Jeffrey; Martinez‐Arraras, Joaquin; Olsen, Stephanie; Piatek, Marek; Ranadive, Nandkishore; Randall, William; Rao, Sunder; Rawitscher, David; Rider, James; Sokos, George; Strader, J Russell; Sulemanjee, Nasir; Tahirkheli, Naeem; Trichon, Benjamin; Vanhecke, Thomas; Whellan, David; Abuannadi, Mohammad; Aggarwala, Gaurav; Ahmad, Saad; Artis, Andre; Cheirif, Jorge; Cotarlan, Vladimir; Cox, Jeremy; Eaton, Charles; Florea, Viorel; Frank, Theodore; Friedman, Keith; Ganeshram, Vedampattu; Gass, Alan; Gemignani, Anthony; Hasni, Syed; Hedgepeth, Chester; Itchhaporia, Dipti; Kaluski, Edo; Karim, Amin; Kono, Alan; Lader, Ellis; Lakshminarayanan, Batlagundu; Lewis, Neil; Malhotra, Vinay; Mayer, Nolan; Mohapatra, Robert; Nair, Nandini; O'Brien, Terrence; Pauwaa, Sunil; Rowan, Christopher; Saxena, Sanjeev; Seto, Arnold; Shah, Nishant; Singh, Pradeep; Skopicki, Hal; Stoddard, Marcus; Sweitzer, Nancy |
| Publisher Information: |
Wiley |
| Publication Year: |
2020 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Subject Terms: |
R Medicine (General) |
| Description: |
Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/223953/1/223953.pdf; Teerlink, J. R. et al. (2020) Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials. European Journal of Heart Failure , 22(11), pp. 2160-2171. (doi:10.1002/ejhf.2015 ) (PMID:32985088) (PMCID:PMC7756903) |
| DOI: |
10.1002/ejhf.2015 |
| Availability: |
https://eprints.gla.ac.uk/223953/; https://eprints.gla.ac.uk/223953/1/223953.pdf; https://doi.org/10.1002/ejhf.2015 |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.12E582F |
| Database: |
BASE |