| Title: |
CBL ubiquitin ligase targets translation as a degrader E3 |
| Authors: |
Wicks, Alice T.; Buetow, Lori; Suzuki, Toshiyasu; Schmidt, Tobias; Lilla, Sergio; Macmillan-Jones, Abigail; Turney, Jennifer; Gohlke, Andrea; Bushell, Martin; Hock, Andreas K.; Huang, Danny T. |
| Contributors: |
Beatson Cancer Charity; Cancer Research UK; Biotechnology and Biological Sciences Research Council |
| Source: |
Chemical Science ; volume 17, issue 8, page 4061-4074 ; ISSN 2041-6520 2041-6539 |
| Publisher Information: |
Royal Society of Chemistry (RSC) |
| Publication Year: |
2026 |
| Description: |
The peptidic PROTAC elFTerminator brings CBL and elF4E together and promotes CBL-mediated elF4E degradation. Consequently, protein translation is disrupted. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1039/d5sc06141e |
| Availability: |
https://doi.org/10.1039/d5sc06141e; http://pubs.rsc.org/en/content/articlepdf/2026/SC/D5SC06141E |
| Rights: |
http://creativecommons.org/licenses/by/3.0/ |
| Accession Number: |
edsbas.1328B0EF |
| Database: |
BASE |