| Title: |
Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases |
| Authors: |
Plagnol, V; Howson, JMM; Smyth, DJ; Walker, N; Hafler, JP; Wallace, C; Stevens, H; Jackson, L; Simmonds, MJ; Bingley, PJ; Gough, SC; Todd, JA; Type 1 Diabet Genetics Consortium |
| Source: |
PLOS GENET , 7 (8) , Article e1002216. (2011) |
| Publisher Information: |
PUBLIC LIBRARY SCIENCE |
| Publication Year: |
2011 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENETIC RISK MARKERS; ABO BLOOD GROUPS; BETA-CELL; DISEASE SUSCEPTIBILITY; HELICOBACTER-PYLORI; PERNICIOUS ANEMIA; GASTRIC CARCINOMA; CROHNS-DISEASE; HLA-RISK |
| Description: |
The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the autoimmune thyroid (Graves') disease (AITD) autoantigen thyroid peroxidase (TPOA, n = 8,300), and antibodies against gastric parietal cells (PCA, n = 4,328) that are associated with autoimmune gastritis. Two loci passed a stringent genome-wide significance level (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1319973/1/1319973.pdf; https://discovery.ucl.ac.uk/id/eprint/1319973/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1319973/1/1319973.pdf; https://discovery.ucl.ac.uk/id/eprint/1319973/ |
| Rights: |
open |
| Accession Number: |
edsbas.13413D08 |
| Database: |
BASE |