| Title: |
Long‐term oncological and functional follow‐up in low‐dose‐rate brachytherapy for prostate cancer: results from the prospective nationwide Swiss registry |
| Authors: |
Viktorin‐Baier, Pascal; Putora, Paul M.; Schmid, Hans‐Peter; Plasswilm, Ludwig; Schwab, Christoph; Thoeni, Armin; Hochreiter, Werner; Prikler, Ladislav; Suter, Stefan; Stucki, Patrick; Müntener, Michael; Blick, Nadja; Schiefer, Hans; Güsewell, Sabine; Zürn, Karin; Engeler, Daniel |
| Source: |
BJU International ; volume 125, issue 6, page 827-835 ; ISSN 1464-4096 1464-410X |
| Publisher Information: |
Wiley |
| Publication Year: |
2020 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective To evaluate the long‐term oncological, functional and toxicity outcomes of low‐dose‐rate brachytherapy (LDR‐BT) in relation to risk factors and radiation dose in a prospective multicentre cohort. Patients and Methods Data of patients from 12 Swiss centres undergoing LDR‐BT from September 2004 to March 2018 were prospectively collected. Patients with a follow‐up of ≥3 months were analysed. Functional and oncological outcomes were assessed at ~6 weeks, 6 and 12 months after implantation and annually thereafter. LDR‐BT was performed with 125 I seeds. Dosimetry was done 6 weeks after implantation based on the European Society for Radiotherapy and Oncology recommendations. The Kaplan–Meier method was used for biochemical recurrence‐free survival (BRFS). A prostate‐specific antigen (PSA) rise above the PSA nadir + 2 was defined as biochemical failure. Functional outcomes were assessed by urodynamic measurement parameters and questionnaires. Results Of 1580 patients in the database, 1291 (81.7%) were evaluable for therapy outcome. The median (range) follow‐up was 37.1 (3.0–141.6) months. Better BRFS was found for Gleason score ≤3+4 ( P = 0.03, log‐rank test) and initial PSA level of |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/bju.15003 |
| DOI: |
10.1111/bju.15003/fullpdf |
| Availability: |
http://dx.doi.org/10.1111/bju.15003; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbju.15003; http://onlinelibrary.wiley.com/wol1/doi/10.1111/bju.15003/fullpdf |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.1397FB25 |
| Database: |
BASE |