| Title: |
Cross-protection by SARS vaccines is improved by booster vaccination |
| Authors: |
Dangi, Tanushree; Palacio, Nicole; Sanchez, Sarah; Park, Mincheol; Class, Jacob; Visvabharathy, Lavanya; Ciucci, Thomas; Koralnik, Igor J; Richner, Justin; Macmaster, Pablo Penaloza |
| Source: |
The Journal of Immunology ; volume 208, issue Supplement_1, page 125.21-125.21 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines have shown extraordinary efficacy against SARS-CoV-2. Recently, we demonstrated that prime-boost coronavirus vaccine regimens can protect against heterologous coronaviruses (Dangi, The Journal of Clinical Investigation, 2021). However, it remains unclear whether boosters are required for such cross-protection. In this study, we show that booster immunizations are critical to elicit cross-protection against heterologous coronaviruses. We first vaccinated BALB/c mice intramuscularly with a poxvirus-based SARS-CoV-1 vaccine developed in 2004 (MVA-SARS-CoV-1) and compared cross-protection following an intranasal SARS-CoV-2 challenge, evaluating cross-protection after a prime-only regimen versus a prime-boost regimen. Interestingly, we show cross-protection only in mice that received boosters. We are currently testing the durability of cross-protection elicited by prime-boost vaccine regimens, and we are also extending these results to humans. Overall, our findings provide a rationale for universal coronavirus vaccines, and highlights the importance of boosters as a strategy to broaden cross-protection to other coronaviruses different than SARS-CoV-2. Supported by NIDA DP2 Avenir (1DP2DA051912-01) EREEP Grant Northwestern University |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.208.supp.125.21 |
| Availability: |
https://doi.org/10.4049/jimmunol.208.supp.125.21; https://academic.oup.com/jimmunol/article/208/Supplement_1/125.21/7940341 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.13D7CFD5 |
| Database: |
BASE |