| Title: |
Association of long COVID with health-related quality-of-life outcomes |
| Authors: |
Margolis, David; Klekotka, Paul; Gasser, Robert A.; Finnegan, Rick; Charles, Edgar; Szurgot, Bob; Main, Mark J.; Lacal, Verónica; Salusso, Diego; Nuñez, Sebastian; Rodriguez, Marcelo Rodrigo; Laborde, Luciana; Papasidero, Marcelo; Wehbe, Luis; Gonzalez, Mariana; Voena, Felicitas Fernandez; Alvarez, Tomas; Lopez, Amaru; Huhn, Virginia; D´Andrea Nores, Ulises; Dieser, Pablo; Bordese, Fernando; Mussi, Marisa; de Carvalho Santana, Rodrigo; Bárbaro, Adriana Aparecida Tiraboschi; Santos, Breno; de Cássia Alves Lira, Rita; da Silva, Andre Luiz Machado; Cardoso, Sandra Wagner; Ribeiro, Maria Pia Diniz; Soliva, Nathália; Vasconcellos, Eduardo; Ribeiro, Jorge Eurico; Enéas, Miriam Amaral; Pinto, Jorge; de Morais Caporali, Julia Fonseca; Ferreira, Flávia Gomes Faleiro; Martinez, Norma Erendira Rivera; Lopez, Victor Casildo Bohorquez; Frias, Melchor Victor; Fetalvero, Krystle; Maranan, Alyxzza; Rosa, Jennifer; Coetzer, Thomas; Mohata, Maureen; Lalloo, Umesh; Pillay, Sandy; Madlala, Penelope; Pillay-Ramaya, Larisha; Bennet, Jaclyn Ann; Mwelase, Noluthando; Mbhele, Nokuphiwa; Petrick, Frederick; Joubert, Leonard; Mbali, Rose; Joseph, Natasha; Manentsa, Mmatsie; van der Walt, Eugene; Masilela, Mduduzi Sandile Lawrance; Zwane, Zinhle; Chiperera, Tendai; Mohapi, Lerato; Moonsamy, Suri; Singh, Usha; McHarry, Kirsten; Snyman, Elizma; Lennox, Pieter; Innes, James Craig; Letlape, Oteng; Jonkane, Olebogeng; Brumskine, William; Adonis, Tania; Sein, Ni Ni; Sebe, Modulakgotla; Vahed, Yacoob; Hussen, Nazreen Jeewa; Mitha, Ismail; Cheekati, Vasundhara; Cheekati, Purna; Lummus, Christie; Idarraga, Samuel; Kim, Andrew; Pham, David N.; Kao, Wei-Hsin; Pfeffer, Michael M.; Dominguez, Miriam Batule; Malik, Anju; Bryan, Anna; Arnold, Melanie; Fernandez, Idania; Karpf, Cinzia; Ruiz, Aniuska; Taylor, David; Folkens, Eric; Manne, Jennifer; Yawetz, Sigal; Keenan, Cheryl; Eziri, Emeka; Fichtenbaum, Carl; Baer, Jenifer; Trentman, Sarah; Call, Robert; Vaughan, Leroy; Milstone, Aaron; Slandzicki, Jamie Alex; Wallan, Jessica; Guillory, Clinton; Andrews, Nancy; Hughes, Leslie; Evering, Teresa H.; Berardi, Jonathan; Arar, Celine; Quinn, Randall; Amaya, Jorge P.; Gomez-Martinez, Marissa; Cantu, Luis; Betancourt-Garcia, Monica; Okeke, Nwora Lance; Burns, Charles M.; Haddad, Fadi; Haddad, Victoria; Focil, Augusto; Rosas, Griselda; Moyano, Susana; Rojas, Yaneicy Gonzalez; Aswad, Ahmad; Bukhman, Yevgeniy; Jain, Manish; Bukhman, Eugene; Farah, Humam; McClain, Rebekah; Daar, Eric; Shaik, Sadia; Hatlen, Timothy; Gotur, Deepa; Surber, Joseph; Kingsley, Jeffrey; Pixler, April; Zopo, Alex; Herman, Jack; Herman, Craig; Leon, Ramon; Nikolov, Boris; Vergara, Fernando Gonzalez; Gonzalez, Ana I.; Gonzalez, Noemi; Gelman, Michael; Andriunas, Olga; Jagizarov, Zarema; Westerman, Jan; Davis, David; Sherer, Donna; Dooley, Kelly; Becker, Becky; Wilkins, Adaliah; Pérez, Jose; Roman, Eloy; Fernández, Heriberto; Mocherla, Bharat; Beck, Kelly; Maldonado, Valarie; Veltman, Jennifer; Gandhi, Rajesh; Shea, Katrina; Planchon, Matthew; Herpel, Laura Bogan; Tripathi, Kaushlendra K.; Day, Donald C.; Pullman, John; Williams-Leber, Erin; Johnson, Misty; Hecker, Michelle; Avery, Ann; Hoover, Keila; Monlux, George W.; Juneja, Elizabeth; Wernick, Arthur; Ruiz, Karelia; Hernández, Maureen; Pérez, Yadilys; Taiwo, Babafemi O.; Hawkins, Claudia; Berzins, Baiba; Malvestutto, Carlos; Harber, Heather; Cicarella, Robyn; DeJesus, Edwin; Rolle, Charlotte-Paige; Free, Almena L.; Pulliam, Sallie D.; Weinstein, Debra; Suarez, Rosa M.; Socorro, Ezequiel; Socorro, Estefania; Neytman, Gene; Easley, Raymond; Aziz, Mariam; Swiatek, Joan; Nagpal, Avish; Kompelien, Breanna; McEvoy, Kathryn; Hoover, Susan E.; Lutz, Allison; Just, Jessica; Hernandez, Manuel; Victoria, Yanly B.; Rodriguez, Gabriel; Singh, Upinder; Jagannathan, Prasanna; Pathak, Divya; Ordway, Joshua J.; Heffner, Megan; Weston, Patrick; Weston, Khalilah; Choudhary, Madhu; Sullivano, Jennifer; Osiyemi, Olayemi; Izquierdo, Myriam; Torna, Odelsey; Clemency, Brian; Varughese, Renoj; Lynch, Joshua; Chew, Kara; Khodabakhshian, Aleen; Fortier, Samantha; Coyne, Christopher; Cronin, Alexandrea; Benson, Constance; Hendrickx, Steven; Ramirez, Rosemarie; Luetkemeyer, Anne; Hendler, Suzanne; Dentoni-Lasofsky, Dennis; Rathore, Mobeen; Mahmoudi, Saniyyah; Riaz, Amna; Castro, Mario; Spikes, Leslie; Hall, Chase; Wohl, David; Oakes, Jonathan; Loftis, Amy James; Tebas, Pablo; Short, William; Dube, Michael P.; Khan, Saahir; Mendez, Luis M.; Ignacio, Rachel Bender; McGuffin, Sarah; Jonsson, Chris; Jain, Mamta K.; Senthil, Smruthi; Turner-Gray, Kimberly; Mehta, Sanjay; Smith, David; Lewinski, Mary; Azizad, Masoud; Chow, Christopher; Nakatani, Lisa; Williamson, Derrick; Atriss, Hisham; Caloura, Matthew; Malla, Midhun; Hazard-Jenkins, Hannah; Wilkin, Aimee; Fayssoux, Jamraus; Seagle, Hannah; Presti, Rachel; Haile, Alem |
| Source: |
Scientific Reports |
| Publication Year: |
2026 |
| Collection: |
Carolina Digital Repository (UNC - University of North Carolina) |
| Subject Terms: |
dimensions of mobility; SF-36 domain scores; test; domain; HRQoL; well-characterized; composition; EQ-5D-5L; therapeutic interventions; COVID-19 symptoms; COVID-19 treatment trials; placebo; intervention; greater risk; self-reported health scores; usual activities; associated with impaired HRQoL; conditions; COVID-19; health-related quality-of-life; quality-of-life outcomes; EQ-5D-5L dimensions; exact test; mental component score; associated with greater risk; months; COVID; longer; pain/discomfort; acute COVID-19 |
| Description: |
The association of long COVID with health-related quality-of-life (HrQOL) has not been well-characterized. Participants who received blinded placebo in the ACTIV-2/A5401 outpatient COVID-19 treatment trial were included in an analysis of the association of long COVID with HrQOL (both pre-specified exploratory trial endpoints) 9 months after acute COVID-19. Long COVID was defined as presence of self-assessed COVID-19 symptoms and HrQOL was assessed with EQ-5D-5L and SF-36v2 questionnaires. Associations were evaluated by Fisher’s exact tests and Wilcoxon rank-sum tests. Of 546 participants, 13% had long COVID. Long COVID was associated with greater risk of reported problems in the EQ-5D-5L dimensions of mobility, usual activities, pain/discomfort, and anxiety/depression (risk ratios 3.45–6.00, all p < 0.001) and worse self-reported health scores (median 80 vs. 95, p < 0.001). Participants with long COVID also had worse SF-36v2 composite physical and mental component scores (both p < 0.001) and individual SF-36 domain scores (physical functioning, physical role, bodily pain, general health, vitality, social functioning, emotional role, and mental health; all p < 0.001). Associations were similar regardless of baseline (pre-COVID-19) medical history. Long COVID is associated with impaired HrQOL across multiple domains, highlighting the need to develop preventative and therapeutic interventions for this protean condition. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://cdr.lib.unc.edu/downloads/v692tq83q?file=thumbnail; https://cdr.lib.unc.edu/downloads/v692tq83q |
| DOI: |
10.17615/k3gw-9084 |
| Availability: |
https://doi.org/10.17615/k3gw-9084; https://cdr.lib.unc.edu/downloads/v692tq83q?file=thumbnail; https://cdr.lib.unc.edu/downloads/v692tq83q |
| Rights: |
http://rightsstatements.org/vocab/InC/1.0/ ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.13E2463D |
| Database: |
BASE |