Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM?
| Title: | Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM? |
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| Authors: | Gras, Luuk; Geskus, Ronald B.; Jurriaans, Suzanne; Bakker, Margreet; van Sighem, Ard; Bezemer, Daniela; Fraser, Christophe; Prins, Jan M.; Berkhout, Ben; Prins, J. M.; Kuijpers, T. W.; Scherpbier, H. J.; Boer, K.; van der Meer, J. T.M.; Wit, F. W.M.N.; Godfried, M. H.; Reiss, P.; van der Poll, T.; Nellen, F. J.B.; Lange, J. M.A.; Geerlings, S. E.; van Vugt, M.; Vrouenraets, S. M.E.; Pajkrt, D.; Bos, J. C.; van der Valk, M.; Schreij, G.; Lowe, S.; Oude Lashof, A.; Pronk, M. J.H.; Bravenboer, B.; van der Ende, M. E.; de Vries-Sluijs, T. E.M.S.; Schurink, C. A.M.; van der Feltz, M.; Nouwen, J. L.; Gelinck, L. B.S.; Verbon, A.; Rijnders, B. J.A.; van de Ven-de Ruiter, E. D.; Slobbe, L.; Kauffmann, R. H.; Schippers, E. F.; Groeneveld, P. H.P.; Alleman, M. A.; Bouwhuis, J. W.; ten Kate, R. W.; Soetekouw, R.; Kroon, F. P.; van den Broek, P. J.; van Dissel, J. T.; Arend, S. M.; van Nieuwkoop, C.; de Boer, M. G.J.; Jolink, H.; den Hollander, J. G.; Pogany, K.; Bronsveld, W.; Kortmann, W.; van Twillert, G.; van Houte, D. P.F.; Polée, M. B.; van Vonderen, M. G.A.; ten Napel, C. H.H.; Kootstra, G. J.; Brinkman, K.; Blok, W. L.; Frissen, P. H.J.; Schouten, W. E.M.; van den Berk, G. E.L.; Juttmann, J. R.; van Kasteren, M. E.E.; Brouwer, A. E.; Mulder, J. W.; van Gorp, E. C.M.; Smit, P. M.; Weijer, S.; van Eeden, A.; Verhagen, D. W.M.; Sprenger, H. G.; Doedens, R.; Scholvinck, E. H.; van Assen, S.; Stek, C. J.; Hoepelman, I. M.; Mudrikova, T.; Schneider, M. M.E.; Jaspers, C. A.J.J.; Ellerbroek, P. M.; Peters, E. J.G.; Maarschalk-Ellerbroek, L. J.; Oosterheert, J. J.; Arends, J. E.; Wassenberg, M. W.M.; van der Hilst, J. C.H.; Richter, C.; van der Berg, J. P.; Gisolf, E. H. |
| Source: | Gras, L, Geskus, R B, Jurriaans, S, Bakker, M, van Sighem, A, Bezemer, D, Fraser, C, Prins, J M, Berkhout, B, Prins, J M, Kuijpers, T W, Scherpbier, H J, Boer, K, van der Meer, J T M, Wit, F W M N, Godfried, M H, Reiss, P, van der Poll, T, Nellen, F J B, Lange, J M A, Geerlings, S E, van Vugt, M, Vrouenraets, S M E, Pajkrt, D, Bos, J C, van der Valk, M, Schreij, G, Lowe, S, Oude Lashof, A, Pronk, M J H, Bravenboer, B, van der Ende, M E, de Vries-Sluijs, .... |
| Publication Year: | 2013 |
| Description: | Introduction:Studies suggest that the HIV-1 epidemic in the Netherlands may have become more virulent, leading to faster disease progression if untreated. Analysis of CD4 cell count decline before antiretroviral therapy (ART) initiation, a surrogate marker for disease progression, may be hampered by informative censoring as ART initiation is more likely with a steeper CD4 cell count decline.Methods:Development of CD4 cell count from 9 to 48 months after seroconversion was analyzed using a mixed-effects model and 2 models that jointly modeled CD4 cell counts and time to censoring event (start ART, |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/23724048; info:eu-repo/semantics/altIdentifier/pissn/1932-6203; info:eu-repo/semantics/altIdentifier/eissn/1932-6203 |
| DOI: | 10.1371/journal.pone.0064437 |
| Availability: | https://research.vumc.nl/en/publications/c59cdfdb-190c-4c43-8e0b-11ae766a7947; https://doi.org/10.1371/journal.pone.0064437; https://www.scopus.com/pages/publications/84878310916 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.148FBC16 |
| Database: | BASE |