| Title: |
Pretreatment human immunodeficiency virus type 1 (HIV-1) drug resistance in transmission clusters of the Cologne-Bonn region, Germany |
| Authors: |
Stecher, M; Chaillon, A; Eis-Hübinger, AM; Lehmann, C; Fätkenheuer, G; Wasmuth, J-C; Knops, E; Vehreschild, JJ; Mehta, S; Hoenigl, M |
| Source: |
Clinical Microbiology and Infection, vol 25, iss 2 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2019 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3207 Medical Microbiology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); HIV/AIDS (rcdc); Sexually Transmitted Infections (rcdc); Infectious Diseases (rcdc); Antimicrobial Resistance (rcdc); Genetics (rcdc); Infection (hrcs-hc); Adult (mesh); Anti-HIV Agents (mesh); Drug Resistance; Viral (mesh); Female (mesh); Germany (mesh); HIV Infections (mesh); HIV-1 (mesh); Humans (mesh); Male (mesh); Middle Aged (mesh); Cluster; Drug-resistant mutations; Human immunodeficiency virus; Network analysis; Phylogenetic analysis |
| Subject Geographic: |
253.e1 - 253.e4 |
| Description: |
OBJECTIVES: In Germany, previous reports have demonstrated transmitted human immunodeficiency virus type 1 (HIV-1) drug-resistance mutations (DRM) in 11% of newly diagnosed individuals, highlighting the importance of drug-resistance screening before the initiation of antiretroviral therapy (ART). Here, we sought to understand the molecular epidemiology of HIV DRM transmission in the Cologne-Bonn region of Germany, given one of the highest rates of new HIV diagnoses in western Europe (13.7 per 100000 habitants). METHODS: We analysed 714 HIV-1 ART-naive infected individuals diagnosed at the University Hospitals Cologne and Bonn between 2001 and 2016. Screening for DRM was performed according to the Stanford University Genotypic Resistance Interpretation. Shared DRM were defined as any DRM present in genetically linked individuals ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt5996j79z; https://escholarship.org/uc/item/5996j79z; https://escholarship.org/content/qt5996j79z/qt5996j79z.pdf |
| DOI: |
10.1016/j.cmi.2018.09.025 |
| Availability: |
https://escholarship.org/uc/item/5996j79z; https://escholarship.org/content/qt5996j79z/qt5996j79z.pdf; https://doi.org/10.1016/j.cmi.2018.09.025 |
| Rights: |
public |
| Accession Number: |
edsbas.14DF31D2 |
| Database: |
BASE |