| Title: |
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study |
| Authors: |
Evans, RA; Leavy, OC; Richardson, M; Elneima, O; McCauley, HJC; Shikotra, A; Singapuri, A; Sereno, M; Saunders, RM; Harris, VC; Houchen-Wolloff, L; Aul, R; Beirne, P; Bolton, CE; Brown, JS; Choudhury, G; Diar-Bakerly, N; Easom, N; Echevarria, C; Fuld, J; Hart, N; Hurst, J; Jones, MG; Parekh, D; Pfeffer, P; Rahman, NM; Rowland-Jones, SL; Shah, AM; Wootton, DG; Chalder, T; Davies, MJ; De Soyza, A; Geddes, JR; Greenhalf, W; Greening, NJ; Heaney, LG; Heller, S; Howard, LS; Jacob, J; Jenkins, RG; Lord, JM; Man, WD-C; McCann, GP; Neubauer, S; Openshaw, PJM; Porter, JC; Rowland, MJ; Scott, JT; Semple, MG; Singh, SJ; Thomas, DC; Toshner, M; Lewis, KE; Thwaites, RS; Briggs, A; Docherty, AB; Kerr, S; Lone, NI; Quint, J; Sheikh, A; Thorpe, M; Zheng, B; Chalmers, JD; Ho, LP; Horsley, A; Marks, M; Poinasamy, K; Raman, B; Harrison, EM; Wain, LV; Brightling, CE; Abel, K; Adamali, H; Adeloye, D; Adeyemi, O; Adrego, R; Jimenez, LAA; Ahmad, S; Haider, NA; Ahmed, R; Ahwireng, N; Ainsworth, M; Al-Sheklly, B; Alamoudi, A; Ali, M; Aljaroof, M; All, AM; Allan, L; Allen, RJ; Allerton, L; Allsop, L; Almeida, P; Altmann, D; Corral, MA; Amoils, S; Anderson, D; Antoniades, C; Arbane, G; Arias, A; Armour, C; Armstrong, L; Armstrong, N; Arnold, D; Arnold, H; Ashish, A; Ashworth, A; Ashworth, M; Aslani, S; Assefa-Kebede, H; Atkin, C; Atkin, P; Aung, H; Austin, L; Avram, C; Ayoub, A; Babores, M; Baggott, R; Bagshaw, J; Baguley, D; Bailey, L; Baillie, JK; Bain, S; Bakali, M; Bakau, M; Baldry, E; Baldwin, D; Ballard, C; Banerjee, A; Bang, B; Barker, RE; Barman, L; Barratt, S; Barrett, F; Basire, D; Basu, N; Bates, M; Bates, A; Batterham, R; Baxendale, H; Bayes, H; Beadsworth, M; Beckett, P; Beggs, M; Begum, M; Bell, D; Bell, R; Bennett, K; Beranova, E; Bermperi, A; Berridge, A; Berry, C; Betts, S; Bevan, E; Bhui, K; Bingham, M; Birchall, K; Bishop, L; Bisnauthsing, K; Blaikely, J; Bloss, A; Bolger, A; Bonnington, J; Botkai, A; Bourne, C; Bourne, M; Bramham, K; Brear, L; Breen, G; Breeze, J; Bright, E; Brill, S; Brindle, K; Broad, L; Broadley, A; Brookes, C; Broome, M; Brown, A; Brown, J; Brown, M; Brown, V; Brown, CW; Brugha, T; Brunskill, N; Buch, M; Buckley, P; Bularga, A; Bullmore, E; Burden, L; Burdett, T; Burn, D; Burns, G; Burns, A; Busby, J; Butcher, R; Butt, A; Byrne, S; Cairns, P; Calder, PC; Calvelo, E; Carborn, H; Card, B; Carr, C; Carr, L; Carson, G; Carter, P; Casey, A; Cassar, M; Cavanagh, J; Chablani, M; Chambers, RC; Chan, F; Channon, KM; Chapman, K; Charalambou, A; Chaudhuri, N; Checkley, A; Chen, J; Cheng, Y; Chetham, L; Childs, C; Chilvers, ER; Chinoy, H; Chiribiri, A; Chong-James, K; Choudhury, N; Chowienczyk, P; Christie, C; Chrystal, M; Clark, D; Clark, C; Clarke, J; Clohisey, S; Coakley, G; Coburn, Z; Coetzee, S; Cole, J; Coleman, C; Conneh, F; Connell, D; Connolly, B; Connor, L; Cook, A; Cooper, B; Cooper, J; Cooper, S; Copeland, D; Cosier, T; Coulding, M; Coupland, C; Cox, E; Craig, T; Crisp, P; Cristiano, D; Crooks, MG; Cross, A; Cruz, I; Cullinan, P; Cuthbertson, D; Daines, L; Dalton, M; Daly, P; Daniels, A; Dark, P; Dasgin, J; David, A; David, C; Davies, E; Davies, F; Davies, G; Davies, GA; Davies, K; Dawson, J; Daynes, E; Deakin, B; Deans, A; Deas, C; Deery, J; Defres, S; Dell, A; Dempsey, K; Denneny, E; Dennis, J; Dewar, A; Dharmagunawardena, R; Dickens, C; Dipper, A; Diver, S; Diwanji, SN; Dixon, M; Djukanovic, R; Dobson, H; Dobson, SL; Donaldson, A; Dong, T; Dormand, N; Dougherty, A; Dowling, R; Drain, S; Draxlbauer, K; Drury, K; Dulawan, P; Dunleavy, A; Dunn, S; Earley, J; Edwards, S; Edwardson, C; El-Taweel, H; Elliott, A; Elliott, K; Ellis, Y; Elmer, A; Evans, D; Evans, H; Evans, J; Evans, R; Evans, RI; Evans, T; Evenden, C; Evison, L; Fabbri, L; Fairbairn, S; Fairman, A; Fallon, K; Faluyi, D; Favager, C; Fayzan, T; Featherstone, J; Felton, T; Finch, J; Finney, S; Finnigan, J; Finnigan, L; Fisher, H; Fletcher, S; Flockton, R; Flynn, M; Foot, H; Foote, D; Ford, A; Forton, D; Fraile, E; Francis, C; Francis, R; Francis, S; Frankel, A; Fraser, E; Free, R; French, N; Fu, X; Furniss, J; Garner, L; Gautam, N; George, J; George, P; Gibbons, M; Gill, M; Gilmour, L; Gleeson, F; Glossop, J; Glover, S; Goodman, N; Goodwin, C; Gooptu, B; Gordon, H; Gorsuch, T; Greatorex, M; Greenhaff, PL; Greenhalgh, A; Greenwood, J; Gregory, H; Gregory, R; Grieve, D; Griffin, D; Griffiths, L; Guerdette, A-M; Guio, BG; Gummadi, M; Gupta, A; Gurram, S; Guthrie, E; Guy, Z; Henson, HH; Hadley, K; Haggar, A; Hainey, K; Hairsine, B; Haldar, P; Hall, I; Hall, L; Halling-Brown, M; Hamil, R; Hancock, A; Hancock, K; Hanley, NA; Haq, S; Hardwick, HE; Hardy, E; Hardy, T; Hargadon, B; Harrington, K; Harris, E; Harrison, P; Harvey, A; Harvey, M; Harvie, M; Haslam, L; Havinden-Williams, M; Hawkes, J; Hawkings, N; Haworth, J; Hayday, A; Haynes, M; Hazeldine, J; Hazelton, T; Heeley, C; Heeney, JL; Heightman, M; Henderson, M; Hesselden, L; Hewitt, M; Highett, V; Hillman, T; Hiwot, T; Hoare, A; Hoare, M; Hockridge, J; Hogarth, P; Holbourn, A; Holden, S; Holdsworth, L; Holgate, D; Holland, M; Holloway, L; Holmes, K; Holmes, M; Holroyd-Hind, B; Holt, L; Hormis, A; Hosseini, A; Hotopf, M; Howard, K; Howell, A; Hufton, E; Hughes, AD; Hughes, J; Hughes, R; Humphries, A; Huneke, N; Hurditch, E; Husain, M; Hussell, T; Hutchinson, J; Ibrahim, W; Ilyas, F; Ingham, J; Ingram, L; Ionita, D; Isaacs, K; Ismail, K; Jackson, T; James, WY; Jarman, C; Jarrold, I; Jarvis, H; Jastrub, R; Jayaraman, B; Jezzard, P; Jiwa, K; Johnson, C; Johnson, S; Johnston, D; Jolley, CJ; Jones, D; Jones, G; Jones, H; Jones, I; Jones, L; Jones, S; Jose, S; Kabir, T; Kaltsakas, G; Kamwa, V; Kanellakis, N; Kaprowska, S; Kausar, Z; Keenan, N; Kelly, S; Kemp, G; Kerslake, H; Key, AL; Khan, F; Khunti, K; Kilroy, S; King, B; King, C; Kingham, L; Kirk, J; Kitterick, P; Klenerman, P; Knibbs, L; Knight, S; Knighton, A; Kon, O; Kon, S; Kon, SS; Koprowska, S; Korszun, A; Koychev, I; Kurasz, C; Kurupati, P; Laing, C; Lamlum, H; Landers, G; Langenberg, C; Lasserson, D; Lavelle-Langham, L; Lawrie, A; Lawson, C; Layton, A; Lea, A; Lee, D; Lee, J-H; Lee, E; Leitch, K; Lenagh, R; Lewis, D; Lewis, J; Lewis, V; Lewis-Burke, N; Li, X; Light, T; Lightstone, L; Lilaonitkul, W; Lim, L; Linford, S; Lingford-Hughes, A; Lipman, M; Liyanage, K; Lloyd, A; Logan, S; Lomas, D; Loosley, R; Lota, H; Lovegrove, W; Lucey, A; Lukaschuk, E; Lye, A; Lynch, C; MacDonald, S; MacGowan, G; Macharia, I; Mackie, J; Macliver, L; Madathil, S; Madzamba, G; Magee, N; Magtoto, MM; Mairs, N; Majeed, N; Major, E; Malein, F; Malim, M; Mallison, G; Mandal, S; Mangion, K; Manisty, C; Manley, R; March, K; Marciniak, S; Marino, P; Mariveles, M; Marouzet, E; Marsh, S; Marshall, B; Marshall, M; Martin, J; Martineau, A; Martinez, LM; Maskell, N; Matila, D; Matimba-Mupaya, W; Matthews, L; Mbuyisa, A; McAdoo, S; McCall, JW; McAllister-Williams, H; McArdle, A; McArdle, P; McAulay, D; McCormick, J; McCormick, W; McCourt, P; McGarvey, L; McGee, C; Mcgee, K; McGinness, J; McGlynn, K; McGovern, A; McGuinness, H; McInnes, IB; McIntosh, J; McIvor, E; McIvor, K; McLeavey, L; McMahon, A; McMahon, MJ; McMorrow, L; Mcnally, T; McNarry, M; McNeill, J; McQueen, A; McShane, H; Mears, C; Megson, C; Megson, S; Mehta, P; Meiring, J; Melling, L; Mencias, M; Menzies, D; Morillas, MM; Michael, A; Milligan, L; Miller, C; Mills, C; Mills, NL; Milner, L; Misra, S; Mitchell, J; Mohamed, A; Mohamed, N; Mohammed, S; Molyneaux, PL; Monteiro, W; Moriera, S; Morley, A; Morrison, L; Morriss, R; Morrow, A; Moss, AJ; Moss, P; Motohashi, K; Msimanga, N; Mukaetova-Ladinska, E; Munawar, U; Murira, J; Nanda, U; Nassa, H; Nasseri, M; Neal, A; Needham, R; Neill, P; Newell, H; Newman, T; Newton-Cox, A; Nicholson, T; Nicoll, D; Nolan, CM; Noonan, MJ; Norman, C; Novotny, P; Nunag, J; Nwafor, L; Nwanguma, U; Nyaboko, J; O'Donnell, K; O'Brien, C; O'Brien, L; O'Regan, D; Odell, N; Ogg, G; Olaosebikan, O; Oliver, C; Omar, Z; Orriss-Dib, L; Osborne, L; Osbourne, R; Ostermann, M; Overton, C; Owen, J; Oxton, J; Pack, J; Pacpaco, E; Paddick, S; Painter, S; Pakzad, A; Palmer, S; Papineni, P; Paques, K; Paradowski, K; Pareek, M; Parfrey, H; Pariante, C; Parker, S; Parkes, M; Parmar, J; Patale, S; Patel, B; Patel, M; Patel, S; Pattenadk, D; Pavlides, M; Payne, S; Pearce, L; Pearl, JE; Peckham, D; Pendlebury, J; Peng, Y; Pennington, C; Peralta, I; Perkins, E; Peterkin, Z; Peto, T; Petousi, N; Petrie, J; Phipps, J; Pimm, J; Hanley, KP; Pius, R; Plant, H; Plein, S; Plekhanova, T; Plowright, M; Polgar, O; Poll, L; Porter, J; Portukhay, S; Powell, N; Prabhu, A; Pratt, J; Price, A; Price, C; Price, D; Price, L; Prickett, A; Propescu, J; Pugmire, S; Quaid, S; Quigley, J; Qureshi, H; Qureshi, IN; Radhakrishnan, K; Ralser, M; Ramos, A; Ramos, H; Rangeley, J; Rangelov, B; Ratcliffe, L; Ravencroft, P; Reddington, A; Reddy, R; Redfearn, H; Redwood, D; Reed, A; Rees, M; Rees, T; Regan, K; Reynolds, W; Ribeiro, C; Richards, A; Richardson, E; Rivera-Ortega, P; Roberts, K; Robertson, E; Robinson, E; Robinson, L; Roche, L; Roddis, C; Rodger, J; Ross, A; Ross, G; Rossdale, J; Rostron, A; Rowe, A; Rowland, A; Rowland, J; Roy, K; Roy, M; Rudan, I; Russell, R; Russell, E; Saalmink, G; Sabit, R; Sage, EK; Samakomva, T; Samani, N; Sampson, C; Samuel, K; Samuel, R; Sanderson, A; Sapey, E; Saralaya, D; Sargant, J; Sarginson, C; Sass, T; Sattar, N; Saunders, K; Saunders, P; Saunders, LC; Savill, H; Saxon, W; Sayer, A; Schronce, J; Schwaeble, W; Scott, K; Selby, N; Sewell, TA; Shah, K; Shah, P; Shankar-Hari, M; Sharma, M; Sharpe, C; Sharpe, M; Shashaa, S; Shaw, A; Shaw, K; Shaw, V; Shelton, S; Shenton, L; Shevket, K; Short, J; Siddique, S; Siddiqui, S; Sidebottom, J; Sigfrid, L; Simons, G; Simpson, J; Simpson, N; Singh, C; Singh, S; Sissons, D; Skeemer, J; Slack, K; Smith, A; Smith, D; Smith, S; Smith, J; Smith, L; Soares, M; Solano, TS; Solly, R; Solstice, AR; Soulsby, T; Southern, D; Sowter, D; Spears, M; Spencer, LG; Speranza, F; Stadon, L; Stanel, S; Steele, N; Steiner, M; Stensel, D; Stephens, G; Stephenson, L; Stern, M; Stewart, I; Stimpson, R; Stockdale, S; Stockley, J; Stoker, W; Stone, R; Storrar, W; Storrie, A; Storton, K; Stringer, E; Strong-Sheldrake, S; Stroud, N; Subbe, C; Sudlow, CL; Suleiman, Z; Summers, C; Summersgill, C; Sutherland, D; Sykes, DL; Sykes, R; Talbot, N; Tan, AL; Tarusan, L; Tavoukjian, V; Taylor, A; Taylor, C; Taylor, J; Te, A; Tedd, H; Tee, CJ; Teixeira, J; Tench, H; Terry, S; Thackray-Nocera, S; Thaivalappil, F; Thamu, B; Thickett, D; Thomas, C; Thomas, S; Thomas, AK; Thomas-Woods, T; Thompson, T; Thompson, AAR; Thornton, T; Tilley, J; Tinker, N; Tiongson, GF; Tobin, M; Tomlinson, J; Tong, C; Touyz, R; Tripp, KA; Tunnicliffe, E; Turnbull, A; Turner, E; Turner, S; Turner, V; Turner, K; Turney, S; Turtle, L; Turton, H; Ugoji, J; Ugwuoke, R; Upthegrove, R; Valabhji, J; Ventura, M; Vere, J; Vickers, C; Vinson, B; Wade, E; Wade, P; Wainwright, T; Wajero, LO; Walder, S; Walker, S; Wall, E; Wallis, T; Walmsley, S; Walsh, JA; Walsh, S; Warburton, L; Ward, TJC; Warwick, K; Wassall, H; Waterson, S; Watson, E; Watson, L; Watson, J; Welch, C; Welch, H; Welsh, B; Wessely, S; West, S; Weston, H; Wheeler, H; White, S; Whitehead, V; Whitney, J; Whittaker, S; Whittam, B; Whitworth, V; Wight, A; Wild, J; Wilkins, M; Wilkinson, D; Williams, N; Williams, J; Williams-Howard, SA; Willicombe, M; Willis, G; Willoughby, J; Wilson, A; Wilson, D; Wilson, I; Window, N; Witham, M; Wolf-Roberts, R; Wood, C; Woodhead, F; Woods, J; Wormleighton, J; Worsley, J; Wraith, D; Wright, C; Wright, L; Wright, S; Wyles, J; Wynter, I; Xu, M; Yasmin, N; Yasmin, S; Yates, T; Yip, KP; Young, B; Young, S; Young, A; Yousuf, AJ; Zawia, A; Zeidan, L; Zhao, B; Zongo, O |
| Publisher Information: |
Elsevier |
| Publication Year: |
2022 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Background No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge. Methods The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing. Findings 2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obesity (0·50 [0·34–0·74]) and invasive mechanical ventilation (0·42 [0·23–0·76]). Cluster analysis (n=1636) corroborated the previously ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2213-2600 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/186761/1/1-s2.0-S2213260022001278-main.pdf; Evans, RA, Leavy, OC, Richardson, M et al. (1003 more authors) (2022) Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine, 10 (8). pp. 761-775. ISSN: 2213-2600 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/186761/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.156B0764 |
| Database: |
BASE |