| Title: |
The Oral Gonadotropin-releasing Hormone Receptor Antagonist Relugolix as Neoadjuvant/Adjuvant Androgen Deprivation Therapy to External Beam Radiotherapy in Patients with Localised Intermediate-risk Prostate Cancer: A Randomised, Open-label, Parallel-group Phase 2 Trial. |
| Authors: |
Dearnaley, DP; Saltzstein, DR; Sylvester, JE; Karsh, L; Mehlhaff, BA; Pieczonka, C; Bailen, JL; Shi, H; Ye, Z; Faessel, HM; Lin, H; Zhu, Y; Saad, F; MacLean, DB; Shore, ND |
| Contributors: |
Dearnaley, David |
| Publisher Information: |
ELSEVIER |
| Publication Year: |
2020 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Description: |
BACKGROUND: External beam radiotherapy (EBRT) with neoadjuvant/adjuvant androgen deprivation therapy (ADT) is an established treatment option to prolong survival for patients with intermediate- and high-risk prostate cancer (PCa). Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, was evaluated in this clinical setting in comparison with degarelix, an injectable GnRH antagonist. OBJECTIVE: To evaluate the safety and efficacy of relugolix to achieve and maintain castration. DESIGN, SETTING, AND PARTICIPANTS: A phase 2 open-label study was conducted in 103 intermediate-risk PCa patients undergoing primary EBRT and neoadjuvant/adjuvant ADT between June 2014 and December 2015. INTERVENTION: Patients randomly assigned (3:2) to 24-wk treatment with either daily oral relugolix or 4-wk subcutaneous depot degarelix (reference control). OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary endpoint was the rate of effective castration (testosterone |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; 192; application/pdf |
| Language: |
English |
| ISSN: |
1873-7560; 0302-2838 |
| Relation: |
European urology, 2020, 78 (2), pp. 184 - 192; https://repository.icr.ac.uk/handle/internal/3629 |
| DOI: |
10.1016/j.eururo.2020.03.001 |
| Availability: |
https://doi.org/10.1016/j.eururo.2020.03.001; https://repository.icr.ac.uk/handle/internal/3629 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.15CA2EF8 |
| Database: |
BASE |