| Title: |
Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes |
| Authors: |
Subramaniam, Kavitha; Julsgaard, Mette; Hvas, Christian L.; Gearry, Richard B; Gibson, Peter R.; Fallingborg, Jan; Sparrow, Miles P.; Bibby, Bo M.; Connell, William R.; Brown, Steven J.; Kamm, Michael A. |
| Source: |
Inflammatory Bowel Diseases |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2022 |
| Collection: |
Australian National University: ANU Digital Collections |
| Subject Terms: |
anti–tumor necrosis factor alpha; counseling; inflammatory bowel disease; pregnancy; pregnancy outcome |
| Description: |
Background Active inflammatory bowel disease (IBD) adversely affects pregnancy outcomes. Little is known about the risk of relapse after stopping anti–tumor necrosis factor (anti-TNF) treatment during pregnancy. We assessed the risk of relapse before delivery in women who discontinued anti-TNF treatment before gestational week (GW) 30, predictors of reduced infant birth weight, a marker associated with long-term adverse outcomes, and rates and satisfaction with counseling. Methods Pregnant women with IBD receiving anti-TNF treatment were prospectively invited to participate in an electronic questionnaire carried out in 22 hospitals in Denmark, Australia, and New Zealand from 2011 to 2015. Risk estimates were calculated, and birth weight was investigated using t tests and linear regression. Results Of 175 women invited, 153 (87%) responded. In women in remission, the relapse rate did not differ significantly between those who discontinued anti-TNF before GW 30 (1/46, 2%) compared with those who continued treatment (8/74, 11%; relative risk, 0.20; 95% confidence interval [CI], 0.02 to 1.56; P = 0.08). Relapse (P = 0.001) and continuation of anti-TNF therapy after GW 30 (P = 0.007) were independently associated with reduced mean birth weight by 367 g (95% CI, 145 to 589 g; relapse) and 274 g (95% CI, 77 to 471 g; anti-TNF exposure after GW 30). Of 134 (88%) women who received counseling, 116 (87%) were satisfied with the information provided. Conclusions To minimize fetal exposure in women in remission, discontinuation of anti-TNF before GW 30 seems safe. Relapse and continuation of anti-TNF therapy after GW 30 were each independently associated with lower birth weight, although without an increased risk for birth weight |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/1885/315624 |
| DOI: |
10.1093/ibd/izz110 |
| Availability: |
https://hdl.handle.net/1885/315624; https://doi.org/10.1093/ibd/izz110; https://openresearch-repository.anu.edu.au/bitstreams/602959b0-5c14-40a0-9050-1a37e4c6402f/download; https://openresearch-repository.anu.edu.au/bitstreams/266018d4-9f4d-4b93-bc3b-945ae21036d3/download |
| Rights: |
This journal is © The Royal Society of Chemistry 2024 |
| Accession Number: |
edsbas.15DB819C |
| Database: |
BASE |