| Title: |
Switch of Open-Source Automated Insulin Delivery (AID) System—AndroidAPS to Commercially Available AID Systems in Type 1 Diabetes: The Extension of the CODIAC Study |
| Authors: |
Do, Quoc Dat; Radovnická, Lucie; Hásková, Aneta; Konečná, Judita; Horová, Eva; Grunberger, George; Prázný, Martin; Parkin, Christopher G.; Flekač, Milan; Šoupal, Jan |
| Contributors: |
Ministry of Health, Czech Republic—conceptual development of research organization, General University Hospital in Prague; National Institute for Research of Metabolic and Cardiovascular Diseases Funded by the European Union Next Generation EU; Cooperatio Program, research area Metabolic Diseases, Charles University in Prague |
| Source: |
Diabetes Technology & Therapeutics ; volume 27, issue 11, page 928-936 ; ISSN 1520-9156 1557-8593 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2025 |
| Description: |
Objective: This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G (780G) conducted in a new extended follow-up study. Research Design and Methods: In this prospective open-label single-arm clinical trial, 41 adults with type 1 diabetes (age 35 ± 11 years, glycated hemoglobin [HbA1c] 6.4 ± 2.8% [46 ± 6.8 mmol/mol]) who have voluntarily used AAPS entered a total of three study phases. In the first phase, participants continued with AAPS for 3 months. In the second 3-month study phase, all participants initiated CIQ ( n = 25) or 780G ( n = 16). Finally, participants were switched back to the AAPS for the last 3 months phase. Results of the treatment with commercially available AID systems were compared with both AAPS phases. Results: Commercially available systems were comparable to AAPS in achieving time in range (TIR) (84.2 ± 7.6 vs. 85 ± 6.9%; P = 0.31) and in HbA1c (6.4 ± 3 vs. 6.3 ± 2.7% [46 ± 8.8 vs. 45.7 ± 6.2 mmol/mol]; P = 0.68). In contrast, time in tight range (TITR) was significantly higher in AAPS (66.38 ± 11.84 vs. 63.4 ± 11.77, P = 0.035). However, the time in hypoglycemia |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/15209156251376013 |
| Availability: |
https://doi.org/10.1177/15209156251376013; https://journals.sagepub.com/doi/full-xml/10.1177/15209156251376013; https://journals.sagepub.com/doi/pdf/10.1177/15209156251376013 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.15DEFEF0 |
| Database: |
BASE |