| Title: |
Treatment‐related determinants of survival in early‐stage (T1–2N0M0) oral cavity cancer: A population‐based study |
| Authors: |
Sowder, Justin C.; Cannon, Richard B.; Buchmann, Luke O.; Hunt, Jason P.; Hitchcock, Ying; Lloyd, Shane; Grossmann, Kenneth F.; Monroe, Marcus M. |
| Source: |
Head & Neck ; volume 39, issue 5, page 876-880 ; ISSN 1043-3074 1097-0347 |
| Publisher Information: |
Wiley |
| Publication Year: |
2017 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background National guidelines support both surgical and radiotherapy (RT) as initial treatment options for early‐stage oral cavity squamous cell carcinoma (SCC). There remains limited data evaluating the survival outcomes of RT and the current practice patterns for these lesions. Methods We conducted a retrospective review of 8274 patients in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with T1 to T2N0M0 oral cavity SCC. Primary outcomes were 5‐year overall survival (OS) and disease‐specific survival (DSS). Results Surgical therapy had significantly improved OS (140 months; p < .001) and DSS (217 months; p < .001) compared to surgery with adjuvant RT (104 and 163 months, respectively) and definitive RT (68 and 136 months, respectively). The use of radiation alone was associated with an increased T classification, hard palate, retromolar trigone primary site lesions, and advanced patient age. Conclusion Primary radiation without surgery continues to be used in a subset of early‐stage oral cavity SCCs, in which it is associated with decreased OS and DSS. © 2017 Wiley Periodicals, Inc. Head Neck 39: 876–880, 2017 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/hed.24679 |
| Availability: |
https://doi.org/10.1002/hed.24679; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhed.24679; https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.24679 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.15E41958 |
| Database: |
BASE |