| Title: |
Observed Apixaban Anti-Xa Levels in Obese Patients |
| Authors: |
Harkness, Weston; Pipitone, Olivia; Joss, Jacqueline; Schiedler, Michael; Shagavah, Santon; Moore, Ryan; Hsing, Jeff |
| Source: |
Annals of Pharmacotherapy ; volume 56, issue 11, page 1215-1221 ; ISSN 1060-0280 1542-6270 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2022 |
| Description: |
Background: Recent guidelines suggest that, for venous thromboembolism (VTE), standard doses of apixaban are appropriate in patients with body mass index (BMI) >40 kg/m2 or >120 kg. Atrial fibrillation (AF) is excluded from this recommendation. Objective: The goals of our study were to measure and describe anti-Xa levels of patients with a BMI ≥40 kg/m2 and/or a weight ≥120 kg with a clinical indication of AF or VTE who were treated with apixaban, and to determine whether BMI or weight are associated with anti-Xa levels in this population. Methods We conducted an observational cohort study at a single health care system in Oregon, USA. Patients meeting enrollment criteria were recruited and had peak and trough apixaban anti-Xa levels drawn. Results Of 55 patients enrolled, 5 (9%) had peak anti-Xa levels below the reference range and 3 (6%) had trough anti-Xa levels below the reference range. BMI did not significantly correlate with peak or trough anti-Xa levels (r = −0.10, p = 0.45 and r = −0.14, p = 0.31). Weight had a moderate, negative correlation with peak anti-Xa levels (r = −0.42, p = 0.002) and a weak, negative correlation with trough anti-Xa levels (r = −0.32, p = 0.02). Conclusions and Relevance This study provides evidence that anti-Xa levels among obese patients are not substantially different from patients with nomral BMI and weight. This supports recent ISTH guidance for standard dosing of apixaban for VTE patients with BMI >40 kg/m2 or weight >120 kg and provides additional evidence that the standard dosing may also be appropriate in patients with AF. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/10600280221077158 |
| Availability: |
https://doi.org/10.1177/10600280221077158; http://journals.sagepub.com/doi/pdf/10.1177/10600280221077158; http://journals.sagepub.com/doi/full-xml/10.1177/10600280221077158 |
| Rights: |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.15EBC9B4 |
| Database: |
BASE |