| Title: |
Childhood socioeconomic position and sex-specific trajectories of metabolic traits across early life: prospective cohort study |
| Authors: |
O'Neill, KN; Bell, JA; Smith, GD; Fraser, A; Howe, LD; Kearney, PM; Robinson, O; Tilling, K; Willeit, P; O'Keeffe, LM |
| Publisher Information: |
Elsevier |
| Publication Year: |
2023 |
| Collection: |
Imperial College London: Spiral |
| Subject Geographic: |
Netherlands |
| Description: |
BACKGROUND: Socioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females than males later in life. Causal atherogenic traits explaining this are not well understood. We explored sex-specific associations between childhood socioeconomic position (SEP) and molecular measures of systemic metabolism across early life. METHODS: Data were from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in southwest England. Pregnant women with an expected delivery date between 1991 and 1992 were invited to participate. Maternal education was the primary indicator of SEP. Concentrations of 148 metabolic traits from targeted metabolomics (nuclear magnetic resonance spectroscopy) from research clinics at ages 7, 15, 18 and 25 years were analysed. The sex-specific slope index of inequality (SII) in trajectories of metabolic traits was estimated using multilevel models. FINDINGS: Total number of participants included was 6537 (12,543 repeated measures). Lower maternal education was associated with more adverse levels of several atherogenic lipids and key metabolic traits among females at age 7 years, but not males. For instance, SII for very small very-low-density lipoprotein (VLDL) concentrations was 0.16SD (95% CI: 0.01, 0.30) among females and -0.02SD (95% CI: -0.16, 0.13) among males. Between 7 and 25 years, inequalities widened among females and emerged among males particularly for VLDL particle concentrations, apolipoprotein-B concentrations, and inflammatory glycoprotein acetyls. For instance, at 25 years, SII for very small VLDL concentrations was 0.36SD (95% CI: 0.20, 0.52) and 0.22SD (95% CI: 0.04, 0.40) among females and males respectively. INTERPRETATION: Prevention of socioeconomic inequalities in cardiovascular disease risk requires a life course approach beginning at the earliest opportunity, especially among females. FUNDING: The UK Medical Research Council and Wellcome (grant ref: 217065/Z/19/Z) and the University of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
EBioMedicine; http://hdl.handle.net/10044/1/108683 |
| DOI: |
10.1016/j.ebiom.2023.104884 |
| Availability: |
http://hdl.handle.net/10044/1/108683; https://doi.org/10.1016/j.ebiom.2023.104884 |
| Rights: |
© 2023 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). ; https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.1611C724 |
| Database: |
BASE |