| Title: |
Prebiotic Environmental Conditions Impact the Type of Iron‐Sulfur Cluster Formed |
| Authors: |
Luca Valer; Yin Juan Hu; Alberto Cini; Marco Lantieri; Craig R. Walton; Oliver Shorttle; Maria Fittipaldi; Sheref S. Mansy |
| Contributors: |
Valer, Luca; Juan Hu, Yin; Cini, Alberto; Lantieri, Marco; Walton, Craig R.; Shorttle, Oliver; Fittipaldi, Maria; Mansy, Sheref S. |
| Publisher Information: |
DEU |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Trento: CINECA IRIS |
| Subject Terms: |
Bioinorganic chemistry; Iron-sulfur cluster; Metallopeptide; Prebiotic chemistry; Prebiotic environments; Settore BIO/10 - Biochimica; Settore BIOS-07/A - Biochimica |
| Description: |
Iron-sulfur clusters are ancient cofactors that could have played a role in the prebiotic chemistry leading to the emergence of protometabolism. Previous research has shown that certain iron-sulfur clusters can form from prebiotically plausible components, such as cysteine-containing oligopeptides. However, it is unclear if these iron-sulfur clusters could have survived in prebiotically plausible environments. To begin exploring this possibility, we tested the stability of iron-sulfur clusters coordinated to a tripeptide and to N-acetyl-L-cysteine methyl ester in a variety of solutions meant to mimic prebiotically plausible environments. We also assessed the impact of individual chemical components on stability. We find that iron-sulfur clusters form over a wide variety of conditions but that the type of iron-sulfur cluster formed is strongly impacted by the chemical environment and the coordinating scaffold. These findings support the general hypothesis that iron-sulfur clusters were present on the prebiotic Earth and that different types of iron-sulfur cluster predominated in different environments. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001345197000001; volume:7; issue:1; firstpage:e202400051; numberofpages:6; journal:CHEMSYSTEMSCHEM; https://hdl.handle.net/11572/459330 |
| DOI: |
10.1002/syst.202400051 |
| Availability: |
https://hdl.handle.net/11572/459330; https://doi.org/10.1002/syst.202400051; https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/syst.202400051 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.163D5B69 |
| Database: |
BASE |