| Title: |
Frailty is associated with in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands:the COVID-OLD study |
| Authors: |
Blomaard,Laura C.; van der Linden,Carolien M.J.; van der Bol,Jessica M.; Jansen,Steffy W.M.; Polinder-Bos,Harmke A.; Willems,Hanna C.; Festen,Jan; Barten,Dennis G.; Borgers,Anke J.; Bos,Jeannet C.; van den Bos, Frederiek; de Brouwer, Esther J.M.; van Deudekom,Floor J.A.; van Dijk,Suzanne C.; Emmelot-Vonk, Mariëlle H.; Geels,Raya E.S.; van de Glind,Esther M.M.; de Groot,Bas; Hempenius,Liesbeth; Kamper,Ad M.; Kampschreur,Linda M.; de Koning,Marre M.M.; Labots,Geert; Looman,Roy; Lucke,Jacinta A.; Maas,Huub A.A.M.; Mattace-Raso,Francesco U.S.; El Moussaoui,Rachida; van Munster,Barbara C.; van Nieuwkoop,Cees; Oosterwijk,Leanne B.L.E.; Regtuijt,Marlies E.M.; Robben,Sarah H.M.; Ruiter,Rikje; Salarbaks,Aisha M.; Schouten,Henrike J.; Smit,Orla M.; Smits,Rosalinde A.L.; Spies,Petra E.; Vreeswijk,Ralph; de Vries,Oscar J.; Wijngaarden,Marjolein A.; Wyers,Caroline E.; Mooijaart,Simon P.; MS Geriatrie; Cancer; Circulatory Health |
| Publication Year: |
2021 |
| Subject Terms: |
clinical frailty scale; COVID-19; frailty; older adults; SARS-CoV-2; Hospital Mortality; Humans; Male; Frailty/complications; COVID-19/mortality; Frail Elderly/statistics & numerical data; Aged; 80 and over; Pandemics/statistics & numerical data; Female; Hospitalization/statistics & numerical data; Retrospective Studies; Netherlands/epidemiology; Geriatrics and Gerontology; Ageing; Journal Article |
| Description: |
BACKGROUND: During the first wave of the coronavirus disease 2019 (COVID-19) pandemic, older patients had an increased risk of hospitalisation and death. Reports on the association of frailty with poor outcome have been conflicting. OBJECTIVE: The aim of the present study was to investigate the independent association between frailty and in-hospital mortality in older hospitalised COVID-19 patients in the Netherlands. METHODS: This was a multicentre retrospective cohort study in 15 hospitals in the Netherlands, including all patients aged ≥70 years, who were hospitalised with clinically confirmed COVID-19 between February and May 2020. Data were collected on demographics, co-morbidity, disease severity and Clinical Frailty Scale (CFS). Primary outcome was in-hospital mortality. RESULTS: A total of 1,376 patients were included (median age 78 years (interquartile range 74-84), 60% male). In total, 499 (38%) patients died during hospital admission. Parameters indicating presence of frailty (CFS 6-9) were associated with more co-morbidities, shorter symptom duration upon presentation (median 4 versus 7 days), lower oxygen demand and lower levels of C-reactive protein. In multivariable analyses, the CFS was independently associated with in-hospital mortality: compared with patients with CFS 1-3, patients with CFS 4-5 had a two times higher risk (odds ratio (OR) 2.0 (95% confidence interval (CI) 1.3-3.0)) and patients with CFS 6-9 had a three times higher risk of in-hospital mortality (OR 2.8 (95% CI 1.8-4.3)). CONCLUSIONS: The in-hospital mortality of older hospitalised COVID-19 patients in the Netherlands was 38%. Frailty was independently associated with higher in-hospital mortality, even though COVID-19 patients with frailty presented earlier to the hospital with less severe symptoms. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0002-0729 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/443067 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/443067 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.16425769 |
| Database: |
BASE |