| Title: |
Impact of infectious comorbidity and overall time of hospitalization in total outpatient management of acute myeloid leukemia patients following venetoclax and hypomethylating agents |
| Authors: |
Papayannidis C.; Cristiano G.; Marconi G.; Sartor C.; Parisi S.; Zannoni L.; Saed R.; Ottaviani E.; Bandini L.; Testoni N.; Baldazzi C.; Solli V.; Ricci P.; Di Giovanni Bezzi C.; Abd-alatif R.; Stanzani M.; Paolini S.; Cavo M.; Curti A.; Nanni J. |
| Contributors: |
Papayannidis C.; Nanni J.; Cristiano G.; Marconi G.; Sartor C.; Parisi S.; Zannoni L.; Saed R.; Ottaviani E.; Bandini L.; Testoni N.; Baldazzi C.; Solli V.; Ricci P.; Di Giovanni Bezzi C.; Abd-alatif R.; Stanzani M.; Paolini S.; Cavo M.; Curti A. |
| Publication Year: |
2022 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
acute myeloid leukemia; hospitalization; hypomethylating agent; infection; outpatient; real life; Venetoclax |
| Description: |
Venetoclax (VEN) and hypomethylating agent (HMAs) regimens are emerging as the standard of care for unfit for chemotherapy acute myeloid leukemia (AML) patients, but the safety and feasibility of a total outpatient management have not been fully investigated. Fifty-nine AML patients with active disease received VEN and HMAs. Nineteen out of 59 (32.2%) patients received the first cycle as inpatients, whereas 40/59 (67.8%) patients were treated in the outpatient setting. No significant differences were observed with regard to incidence of adverse events (AEs), including tumor lysis syndrome (TLS), and the 30-day and 60-day mortality was comparable. Notably, an infectious prophylaxis inspired to that adopted during intensive chemotherapy resulted in a low infection rate with a reduced bacterial infections incidence in out- versus hospitalized patients (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000762097000001; volume:108; issue:6; firstpage:449; lastpage:459; numberofpages:11; journal:EUROPEAN JOURNAL OF HAEMATOLOGY; https://hdl.handle.net/11585/902461 |
| DOI: |
10.1111/ejh.13753 |
| Availability: |
https://hdl.handle.net/11585/902461; https://doi.org/10.1111/ejh.13753; https://onlinelibrary.wiley.com/doi/10.1111/ejh.13753 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.16550A23 |
| Database: |
BASE |