| Title: |
Genome-wide association study of positive emotion identifies a genetic variant and a role for microRNAs |
| Authors: |
Wingo, AP; Almli, LM; Stevens, JS; Jovanovic, T; Wingo, TS; Tharp, G; Li, Y; Lori, A; Briscione, M; Jin, P; Binder, EB; Bradley, B; Gibson, G; Ressler, KJ |
| Source: |
Molecular Psychiatry, vol 22, iss 5 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2017 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
5202 Biological Psychology (for-2020); 3214 Pharmacology and Pharmaceutical Sciences (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 52 Psychology (for-2020); Mental Health (rcdc); Genetics (rcdc); Basic Behavioral and Social Science (rcdc); Behavioral and Social Science (rcdc); Human Genome (rcdc); Biotechnology (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Adult (mesh); Black or African American (mesh); Alleles (mesh); Chromosomes; Human; Pair 1 (mesh); Emotions (mesh); Female (mesh); Gene Frequency (mesh); Genetic Variation (mesh); Genome-Wide Association Study (mesh); Happiness (mesh); Humans (mesh); Introns (mesh); Male (mesh); MicroRNAs (mesh); Middle Aged (mesh); Pleasure (mesh); Polymorphism |
| Subject Geographic: |
774 - 783 |
| Description: |
Positive affect denotes a state of pleasurable engagement with the environment eliciting positive emotion such as contentment, enthusiasm or happiness. Positive affect is associated with favorable psychological, physical and economic outcomes in many longitudinal studies. With a heritability of ⩽64%, positive affect is substantially influenced by genetic factors; however, our understanding of genetic pathways underlying individual differences in positive affect is still limited. Here, through a genome-wide association study of positive affect in African-American participants, we identify a single-nucleotide polymorphism, rs322931, significantly associated with positive affect at P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt1xr4g1xc; https://escholarship.org/uc/item/1xr4g1xc; https://escholarship.org/content/qt1xr4g1xc/qt1xr4g1xc.pdf |
| DOI: |
10.1038/mp.2016.143 |
| Availability: |
https://escholarship.org/uc/item/1xr4g1xc; https://escholarship.org/content/qt1xr4g1xc/qt1xr4g1xc.pdf; https://doi.org/10.1038/mp.2016.143 |
| Rights: |
public |
| Accession Number: |
edsbas.16589AC1 |
| Database: |
BASE |