| Title: |
Mortality surrogates in combined pulmonary fibrosis and emphysema |
| Authors: |
Zhao,An; Gudmundsson,Eyjolfur; Mogulkoc,Nesrin; van Moorsel,Coline; Corte,Tamera J; Vasudev,Pardeep; Romei,Chiara; Chapman,Robert; Wallis,Tim J M; Denneny,Emma; Goos,Tinne; Savas,Recep; Ahmed,Asia; Brereton,Christopher J; van Es,Hendrik W; Jo,Helen; De Liperi,Annalisa; Duncan,Mark; Pontoppidan,Katarina; De Sadeleer,Laurens J; van Beek,Frouke; Barnett,Joseph; Cross,Gary; Procter,Alex; Veltkamp, Marcel; Hopkins,Peter; Moodley,Yuben; Taliani,Alessandro; Taylor,Magali; Verleden,Stijn; Tavanti,Laura; Vermant,Marie; Nair,Arjun; Stewart,Iain; Janes,Sam M; Young,Alexandra L; Barber,David; Alexander,Daniel C; Porter,Joanna C; Wells,Athol U; Jones,Mark G; Wuyts,Wim A; Jacob,Joseph; Longziekten |
| Publication Year: |
2024 |
| Subject Terms: |
Disease Progression; Emphysema/complications; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lung; Pulmonary Emphysema/complications; Retrospective Studies; Taverne; Journal Article |
| Description: |
Background Idiopathic pulmonary fibrosis (IPF) with coexistent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may associate with reduced forced vital capacity (FVC) declines compared to non-CPFE IPF patients. We examined associations between mortality and functional measures of disease progression in two IPF cohorts. Methods Visual emphysema presence (>0% emphysema) scored on computed tomography identified CPFE patients (CPFE/non-CPFE: derivation cohort n=317/n=183, replication cohort n=358/n=152), who were subgrouped using 10% or 15% visual emphysema thresholds, and an unsupervised machine-learning model considering emphysema and interstitial lung disease extents. Baseline characteristics, 1-year relative FVC and diffusing capacity of the lung for carbon monoxide (DLCO) decline (linear mixed-effects models), and their associations with mortality (multivariable Cox regression models) were compared across non-CPFE and CPFE subgroups. Results In both IPF cohorts, CPFE patients with ≥10% emphysema had a greater smoking history and lower baseline DLCO compared to CPFE patients with |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0903-1936 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/451468 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/451468 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.169D031F |
| Database: |
BASE |