| Title: |
Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers |
| Authors: |
Checkoway, H; Lundin, JI; Costello, S; Ray, R; Li, W; Eisen, EA; Astrakianakis, G; Seixas, N; Applebaum, K; Gao, DL; Thomas, DB |
| Source: |
British Journal of Cancer, vol 111, iss 3 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2014 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Prevention (rcdc); Lung (rcdc); Lung Cancer (rcdc); Cancer (rcdc); 2.2 Factors relating to the physical environment (hrcs-rac); Cancer (hrcs-hc); Aged (mesh); Aged; 80 and over (mesh); Air Pollutants (mesh); Carcinogenesis (mesh); Case-Control Studies (mesh); Cotton Fiber (mesh); Dust (mesh); Female (mesh); Humans (mesh); Lipopolysaccharides (mesh); Lung Neoplasms (mesh); Middle Aged (mesh); Occupational Diseases (mesh); Occupational Exposure (mesh); Proportional Hazards Models (mesh); Risk Factors (mesh); endotoxin; lipopolysaccharide; lung cancer; epidemiology; textile industry |
| Subject Geographic: |
603 - 607 |
| Description: |
Background:Endotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure.Methods:We updated a case–cohort study nested within a cohort of 267 400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989–2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure–response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of ⩽15 and >15 years since first exposure.Results:We observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (∼1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure.Conclusions:The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt30p2w8qj; https://escholarship.org/uc/item/30p2w8qj; https://escholarship.org/content/qt30p2w8qj/qt30p2w8qj.pdf |
| DOI: |
10.1038/bjc.2014.308 |
| Availability: |
https://escholarship.org/uc/item/30p2w8qj; https://escholarship.org/content/qt30p2w8qj/qt30p2w8qj.pdf; https://doi.org/10.1038/bjc.2014.308 |
| Rights: |
CC-BY-NC-SA |
| Accession Number: |
edsbas.16C79DF4 |
| Database: |
BASE |