Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis
| Title: | Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis |
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| Authors: | Gervais, Adrian; Marchal, Astrid; Boucherit, Soraya; Abi Haidar, Anthony; Bizien, Lucy; Yalcinkaya, Ahmet; Sandström, Ella; Kong, Xiao Fei; Jacquemin, Emmanuel; Bernard, Olivier; Debray, Dominique; Lacaille, Florence; Ichai, Philippe; Arikan, Cigdem; Javouhey, Etienne; Roquelaure, Bertrand; Gottrand, Frédéric; Trespidi, Francesca; Codullo, Veronica; Cavagna, Lorenzo; Schleinitz, Nicolas; Bousfiha, Mohamed; Amenzoui, Naima; Bousfiha, Ahmed Aziz; Jørgensen, Sofie E.; Mørk, Nanna; Mogensen, Trine H.; Bastard, Paul; Puel, Anne; Borghesi, Alessandro; Rule, Jody A.; Lee, William M.; Landegren, Nils; Cobat, Aurélie; Casanova, Jean Laurent; Jouanguy, Emmanuelle |
| Source: | Gervais, A, Marchal, A, Boucherit, S, Abi Haidar, A, Bizien, L, Yalcinkaya, A, Sandström, E, Kong, X F, Jacquemin, E, Bernard, O, Debray, D, Lacaille, F, Ichai, P, Arikan, C, Javouhey, E, Roquelaure, B, Gottrand, F, Trespidi, F, Codullo, V, Cavagna, L, Schleinitz, N, Bousfiha, M, Amenzoui, N, Bousfiha, A A, Jørgensen, S E, Mørk, N, Mogensen, T H, Bastard, P, Puel, A, Borghesi, A, Rule, J A, Lee, W M, Landegren, N, Cobat, A, Casanova, J L & Jouanguy, E 2026, 'Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis', The Journal of Experimental .... |
| Publication Year: | 2026 |
| Collection: | Aarhus University: Research |
| Description: | Fulminant viral hepatitis (FVH) is a devastating condition caused by hepatotropic viruses such as hepatitis A virus (HAV), hepatitis B virus (HBV), and HSV-1/2. We studied 149 FVH patients (73 males and 76 females, aged 1-76) for blood autoantibodies (auto-Abs) neutralizing type I interferons (IFNs; IFN-α2, -β, -ω). Six of 16 (37.5%) HSV-triggered FVH patients carried such auto-Abs on admission, including three with a previously known autoimmune disease. These patients contrasted with 133 HAV- (n = 46) or HBV-triggered (n = 87) patients, none of whom had such detectable auto-Abs. Odds ratios for HSV-triggered FVH in individuals with auto-Abs ranged from 35.3 (95% CI: 13.0-96.2; P < 10-7) for those neutralizing only 100 pg/ml IFN-α/ω to 1,895 (CI: 448.5-8,002; P < 10-12) for those neutralizing both IFN-α and IFN-ω at 10 ng/ml. Over one third of HSV-triggered FVH cases in this international cohort were due to preexisting auto-Abs. This finding highlights auto-Abs against type I IFNs as a major determinant of HSV-FVH and paves the way for targeted preventive or therapeutic interventions. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 0022-1007; 1540-9538 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41348319; info:eu-repo/semantics/altIdentifier/pissn/0022-1007; info:eu-repo/semantics/altIdentifier/eissn/1540-9538 |
| DOI: | 10.1084/jem.20251760 |
| Availability: | https://pure.au.dk/portal/en/publications/a001d0c4-a7e9-44eb-910e-a3a7876d11c0; https://doi.org/10.1084/jem.20251760; https://www.scopus.com/pages/publications/105023913013 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.16D9D319 |
| Database: | BASE |