| Title: |
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial |
| Authors: |
Ryan, DH; Lingvay, I; Deanfield, J; Kahn, SE; Barros, E; Burguera, B; Colhoun, HM; Cercato, C; Dicker, D; Horn, DB; Hovingh, GK; Jeppesen, OK; Kokkinos, A; Lincoff, AM; Meyhöfer, SM; Oral, TK; Plutzky, J; van Beek, AP; Wilding, JPH; Kushner, RF |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Collection: |
The University of Liverpool Repository |
| Description: |
In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (−10.2%), waist circumference (−7.7 cm) and waist-to-height ratio (−6.9%) versus placebo (−1.5%, −1.3 cm and −1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1078-8956 |
| Relation: |
https://livrepository.liverpool.ac.uk/3183272/1/Long-term%20weight%20loss%20effects%20of%20semaglutide%20in%20obesity%20without%20diabetes%20in%20the%20SELECT%20trial.pdf; Collapse authors list. Ryan, DH, Lingvay, I orcid:0000-0001-7006-7401 , Deanfield, J, Kahn, SE, Barros, E orcid:0000-0001-6613-4181 , Burguera, B, Colhoun, HM orcid:0000-0002-8345-3288 , Cercato, C orcid:0000-0002-6181-4951 , Dicker, D, Horn, DB et al (show 10 more authors) , Hovingh, GK, Jeppesen, OK, Kokkinos, A, Lincoff, AM orcid:0000-0001-8175-2121 , Meyhöfer, SM, Oral, TK, Plutzky, J orcid:0000-0002-7194-9876 , van Beek, AP orcid:0000-0002-0335-8177 , Wilding, JPH orcid:0000-0003-2839-8404 and Kushner, RF (2024) Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial Nature Medicine, 30 (7). pp. 2049-2057. ISSN 1078-8956, 1546-170X |
| DOI: |
10.1038/s41591-024-02996-7 |
| Availability: |
https://livrepository.liverpool.ac.uk/3183272/; https://doi.org/10.1038/s41591-024-02996-7 |
| Accession Number: |
edsbas.16EAA474 |
| Database: |
BASE |