| Title: |
Glycocalyx biomarker levels can predict worse outcomes in trauma patients: a systematic review |
| Authors: |
Nadeem, Aisha; Tabbakh, Judy; Dermanis, Alexander; Harb Nasser, Ahmed Abdul Hadi; Khatib, Muhammad; Elmajee, Mohammed |
| Source: |
Orthoplastic Surgery ; volume 19, issue 2, page 10-16 ; ISSN 2666-769X |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
Background: The endothelial glycocalyx is a luminal layer of the endothelium composed of proteoglycans and glycoproteins. It plays an important role in maintaining vascular homeostasis, alongside providing structural integrity to the endothelium. Shedding of the glycocalyx in trauma patients can have profound impacts on vascular permeability and tissue integrity, causing inflammation and tissue damage. Objectives: The phenomenon of glycocalyx shedding in trauma patients, primarily as a result of coagulopathy and endothelial injury, has been increasingly documented. We aimed to systematically review the correlation between plasma glycocalyx biomarker levels and adverse outcomes in trauma patients. Methods: A systematic review was performed using PubMed, Medline, Embase, and Cochrane library databases. The search terms included the following: Glycocalyx, Syndecan, Syndecan-1, Hyaluronic, Hyaluronic acid, and Outcomes. The inclusion criteria consisted of human in vivo studies of major trauma patients that presented acutely to a major trauma center. Results: Out of the seven included studies, five investigated the correlation between the levels of the glycocalyx biomarker syndecan-1 (SDC-1) and mortality. Four out of these five studies demonstrated that higher SDC-1 levels were significantly and independently associated with a higher risk of mortality. Two out of the seven included studies reported a significant association between glycocalyx biomarker levels and an increased odds of developing trauma-induced coagulopathy. Three studies further demonstrated a significant correlation between glycocalyx levels and other outcomes including higher blood transfusion requirements, longer hospital length of stay (LOS), higher odds of developing an acute kidney injury (AKI), and higher Sequential Organ Failure Assessment (SOFA) scores. Conclusion: Elevated plasma levels of glycocalyx components can independently predict mortality and other adverse outcomes in trauma patients. These findings suggest the prospective value of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/os9.0000000000000003 |
| DOI: |
10.1097/OS9.0000000000000003 |
| Availability: |
https://doi.org/10.1097/os9.0000000000000003; https://journals.lww.com/10.1097/OS9.0000000000000003 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.16F6DA1B |
| Database: |
BASE |