| Title: |
Synbiotic administration improves systemic and vascular alterations in rats with experimental microsurgical extrahepatic cholestasis: role of perivascular mesenteric innervation |
| Authors: |
Méndez-Albiñana, Pablo; Cros-Brunsó, Laia; Rodrigues-Díez, Raquel; Rodríguez-Rodríguez, Pilar; Santamaría Solís, Luis; Muñoz Labrador, Ana; Requena Rolanía, Teresa; Casani, Laura; Caballero Díaz, Francisco Félix; Prieto Nieto, María Isabel; Villamiel Guerra, María del Mar; Blanco Rivero, Javier |
| Contributors: |
Departamento de Fisiología; Departamento de Anatomía, Histología y Neurociencia; Departamento de Medicina Preventiva y Salud Pública y Microbiología; Facultad de Medicina; Gobierno de España |
| Publisher Information: |
Elsevier |
| Publication Year: |
2026 |
| Collection: |
Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| Subject Terms: |
Liver cholestasis; Gut microbiota; Liver function; Renal function; Nervous regulation of vascular tone; Superior mesenteric artery; Synbiotics; Medicina |
| Description: |
Liver cholestasis is marked by bile acid accumulation in the liver, along with renal issues, portal hypertension, and altered circulation. Previous studies suggest that synbiotics may improve systemic and hemodynamic conditions in liver diseases. This study investigated the effects of a commercial synbiotic on gut microbiota, liver and kidney function, and vascular changes in a cholestatic rat model, focusing on nerve functions in the superior mesenteric arteries. Adult male Wistar rats were divided into three groups: Sham-operated, Cholestatic, and Cholestatic supplemented with a synbiotic for 3 weeks, following an initial 3-week postsurgical recovery period for model establishment. The synbiotic did not significantly alter gut microbiota composition, but reduced endotoxemia and increased butyric, acetic, and propionic acid levels. It improved, but did not fully reverse, liver and renal damage. In the synbiotic group, systolic blood pressure normalized to values similar to sham-operated animals, and mesenteric artery vasoconstriction increased in response to electric field stimulation. Although the vasomotor response to noradrenaline (NA) remained unchanged, NA release was higher (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Bioactive Carbohydrates and Dietary Fibre; https://doi.org/10.1016/j.bcdf.2025.100505; Gobierno de España. PID2020-116498RB-100; Gobierno de España. PID2021-123862OB-100; Gobierno de España. PID2022-138610OB-100; Bioactive Carbohydrates and Dietary Fibre 34 (2025): 100505; https://hdl.handle.net/10486/745080; 34; 100505 |
| DOI: |
10.1016/j.bcdf.2025.100505 |
| Availability: |
https://hdl.handle.net/10486/745080; https://doi.org/10.1016/j.bcdf.2025.100505 |
| Rights: |
© 2025 The Authors. Published by Elsevier Ltd. ; Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0/ ; open access |
| Accession Number: |
edsbas.16FB33B3 |
| Database: |
BASE |