| Title: |
Hepatitis c virus viremia increases the Incidence of chronic kidney disease in HIV-infected Patients |
| Authors: |
Peters L.; Grint D.; Lundgren J. D.; Rockstroh J. K.; Soriano V.; Reiss P.; Grzeszczuk A.; Sambatakou H.; Mocroft A.; Kirk O.; Losso M.; Elias C.; Vetter N.; Zangerle R.; Karpov I.; Vassilenko A.; Mitsura V. M.; Suetnov O.; Clumeck N.; De Wit S.; Delforge M.; Colebunders R.; Vandekerckhove L.; Hadziosmanovic V.; Kostov K.; Begovac J.; Machala L.; Jilich D.; Sedlacek D.; Nielsen J.; Kronborg G.; Benfield T.; Larsen M.; Gerstoft J.; Katzenstein T.; Hansen A. -B. E.; Skinhoj P.; Pedersen C.; Ostergaard L.; Zilmer K.; Smidt J.; Ristola M.; Katlama C.; Viard J. -P.; Girard P. -M.; Livrozet J. M.; Vanhems P.; Pradier C.; Dabis F.; Neau D.; Schmidt R.; Van Lunzen J.; Degen O.; Stellbrink H. J.; Staszewski S.; Bogner J.; Fatkenheuer G.; Kosmidis J.; Gargalianos P.; Xylomenos G.; Perdios J.; Panos G.; Filandras A.; Karabatsaki E.; Banhegyi D.; Mulcahy F.; Yust I.; Turner D.; Burke M.; Pollack S.; Hassoun G.; Maayan S.; Vella S.; Esposito R.; Mazeu I.; Mussini C.; Arici C.; Pristera R.; Mazzotta F.; Gabbuti A.; Vullo V.; Lichtner M.; Chirianni A.; Montesarchio E.; Gargiulo M.; Antonucci G.; Testa A.; Narciso P.; Vlassi C.; Zaccarelli M.; Lazzarin A.; Castagna A.; Gianotti N.; Galli M.; Ridolfo A.; D'Arminio Monforte A.; Rozentale B.; Zeltina I.; Chaplinskas S.; Hemmer R.; Staub T.; Ormaasen V.; Maeland A.; Bruun J.; Knysz B.; Gasiorowski J.; Horban A.; Bakowska E.; Flisiak R.; Boron-Kaczmarska A.; Pynka M.; Parczewski M.; Beniowski M.; Mularska E.; Trocha H.; Jablonowska E.; Malolepsza E.; Wojcik K.; Antunes F.; Doroana M.; Caldeira L.; Mansinho K.; Maltez F.; Duiculescu D.; Babes V.; Rakhmanova A.; Zakharova N.; Buzunova S.; Jevtovic D.; Mokras M.; Stanekova D.; Tomazic J.; Gonzalez-Lahoz J.; Labarga P.; Medrano J.; Moreno S.; Rodriguez J. M.; Clotet B.; Jou A.; Paredes R.; Tural C.; Puig J.; Bravo I.; Gatell J. M.; Miro J. M.; Domingo P.; Gutierrez M.; Mateo G.; Sambeat M. A.; Karlsson A.; Flamholc L.; Ledergerber B.; Weber R.; Francioli P.; Cavassini M.; Hirschel B.; Boffi E.; Furrer H.; Battegay M.; Elzi L.; Kravchenko E.; Chentsova N.; Frolov V.; Kutsyna G.; Servitskiy S.; Krasnov M.; Barton S.; Johnson A. M.; Mercey D.; Phillips A.; Johnson M. A.; Murphy M.; Weber J.; Scullard G.; Fisher M.; Leen C. |
| Contributors: |
L. Peter; D. Grint; J.D. Lundgren; J.K. Rockstroh; V. Soriano; P. Rei; A. Grzeszczuk; H. Sambatakou; A. Mocroft; O. Kirk; M. Losso; C. Elia; N. Vetter; R. Zangerle; I. Karpov; A. Vassilenko; V.M. Mitsura; O. Suetnov; N. Clumeck; S. De Wit; M. Delforge; R. Colebunder; L. Vandekerckhove; V. Hadziosmanovic; K. Kostov; J. Begovac; L. Machala; D. Jilich; D. Sedlacek; J. Nielsen; G. Kronborg; T. Benfield; M. Larsen; J. Gerstoft; T. Katzenstein; A.-.E. Hansen; P. Skinhoj; C. Pedersen; L. Ostergaard; K. Zilmer; J. Smidt; M. Ristola; C. Katlama; J.-. Viard; P.-. Girard; J.M. Livrozet; P. Vanhem; C. Pradier; F. Dabi; D. Neau; R. Schmidt; J. Van Lunzen; O. Degen; H.J. Stellbrink; S. Staszewski; J. Bogner; G. Fatkenheuer; J. Kosmidi; P. Gargaliano; G. Xylomeno; J. Perdio; G. Pano; A. Filandra; E. Karabatsaki; D. Banhegyi; F. Mulcahy; I. Yust; D. Turner; M. Burke; S. Pollack; G. Hassoun; S. Maayan; S. Vella; R. Esposito; I. Mazeu; C. Mussini; C. Arici; R. Pristera; F. Mazzotta; A. Gabbuti; V. Vullo; M. Lichtner; A. Chirianni; E. Montesarchio; M. Gargiulo; G. Antonucci; A. Testa; P. Narciso; C. Vlassi; M. Zaccarelli; A. Lazzarin; A. Castagna; N. Gianotti; M. Galli; A. Ridolfo; A. D'Arminio Monforte; B. Rozentale; I. Zeltina; S. Chaplinska; R. Hemmer |
| Publisher Information: |
Lippincott Williams and Wilkins |
| Publication Year: |
2012 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
coinfection; hepatitis C viru; HIV; kidney disease; viremia; AIDS-Associated Nephropathy; Adult; Argentina; Cohort Studie; Creatinine; Disease Progression; Europe; Female; Genotype; Glomerular Filtration Rate; HIV Seropositivity; Hepaciviru; Hepatitis C; Hepatitis C Antibodie; Human; Incidence; Israel; Male; Middle Aged; Prospective Studie; Renal Insufficiency; Chronic; Settore MED/17 - Malattie Infettive |
| Description: |
Background: Several studies have reported on an association between hepatitis C virus (HCV) antibody status and the development of chronic kidney disease (CKD), but the role of HCV viremia and genotype are not well defined. Methods: Patients with at least three serum creatinine measurements after 1 January 2004 and known HCV antibody status were included. Baseline was defined as the first eligible estimated glomerular filtration rate (eGFR) (Cockcroft-Gault equation), and CKD was either a confirmed (>3 months apart) eGFR of 60 ml/min per 1.73m2 or less for patients with a baseline eGFR more than 60 ml/min per 1.73m2 or a confirmed 25% decline in eGFR for patients with a baseline eGFR of 60 ml/min per 1.73m2 or less. Incidence rates of CKD were compared between HCV groups (anti-HCV-negative, anti-HCV-positive with or without viremia) using Poisson regression. Results: Of 8235 patients with known anti-HCV status, 2052 (24.9%) were anti-HCVpositive of whom 983 (47.9%) were HCV-RNA-positive, 193 (9.4%) HCV-RNAnegative and 876 (42.7%) had unknown HCV-RNA. At baseline, the median eGFR was 97.6 (interquartile range 83.8-113.0) ml/min per 1.73m2. During 36123 personyears of follow-up (PYFU), 495 patients progressed to CKD (6.0%) with an incidence rate of 14.5 per 1000 PYFU (95% confidence interval 12.5-14.9). In a multivariate Poisson model, patients who were anti-HCV-positive with HCV viremia had a higher incidence rate of CKD, whereas patients with cleared HCV infection had a similar incidence rate of CKD compared with anti-HCV-negative patients. There was no association between CKD and HCV genotype. Conclusion: Compared with HIV-monoinfected patients, HIV-positive patients with chronic rather than cleared HCV infection were at increased risk of developing CKD, suggesting a contribution from active HCV infection toward the pathogenesis of CKD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/22781222; info:eu-repo/semantics/altIdentifier/wos/WOS:000309224100008; volume:26; issue:15; firstpage:1917; lastpage:1926; numberofpages:10; journal:AIDS; https://hdl.handle.net/2434/774438 |
| DOI: |
10.1097/QAD.0b013e3283574e71 |
| Availability: |
https://hdl.handle.net/2434/774438; https://doi.org/10.1097/QAD.0b013e3283574e71 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.170AADAE |
| Database: |
BASE |