| Title: |
Comorbidities of Keloid and Hypertrophic Scars Among Participants in UK Biobank |
| Authors: |
Ung, Chuin Y; Warwick, Alasdair; Onoufriadis, Alexandros; Barker, Jonathan N; Parsons, Maddy; McGrath, John A; Shaw, Tanya J; Dand, Nick |
| Source: |
JAMA Dermatology , 159 (2) pp. 172-181. (2023) |
| Publisher Information: |
American Medical Association (AMA) |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Importance: Keloids and hypertrophic scars (excessive scarring) are relatively understudied disfiguring chronic skin conditions with high treatment resistance. // Objective: To evaluate established comorbidities of excessive scarring in European individuals, with comparisons across ethnic groups, and to identify novel comorbidities via a phenome-wide association study (PheWAS). // Design, Setting, and Participants: This multicenter cross-sectional population-based cohort study used UK Biobank (UKB) data and fitted logistic regression models for testing associations between excessive scarring and a variety of outcomes, including previously studied comorbidities and 1518 systematically defined disease categories. Additional modeling was performed within subgroups of participants defined by self-reported ethnicity (as defined in UK Biobank). Of 502 701 UKB participants, analyses were restricted to 230078 individuals with linked primary care records. // Exposures: Keloid or hypertrophic scar diagnoses. // Main Outcomes and Measures: Previously studied disease associations (hypertension, uterine leiomyoma, vitamin D deficiency, atopic eczema) and phenotypes defined in the PheWAS Catalog. // Results: Of the 972 people with excessive scarring, there was a higher proportion of female participants compared with the 229 106 controls (65% vs 55%) and a lower proportion of White ethnicity (86% vs 95%); mean (SD) age of the total cohort was 64 (8) years. Associations were identified with hypertension and atopic eczema in models accounting for age, sex, and ethnicity, and the association with atopic eczema (odds ratio [OR], 1.68; 95% CI, 1.36-2.07; P < .001) remained statistically significant after accounting for additional potential confounders. Fully adjusted analyses within ethnic groups revealed associations with hypertension in Black participants (OR, 2.05; 95% CI, 1.13-3.72; P = .02) and with vitamin D deficiency in Asian participants (OR, 2.24; 95% CI, 1.26-3.97; P = .006). The association with uterine leiomyoma was ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10200949/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10200949/1/2022-10-20_DER22-1714R_Merged_PDF-RESUBMITTED.pdf; https://discovery.ucl.ac.uk/id/eprint/10200949/ |
| Rights: |
open |
| Accession Number: |
edsbas.174508F |
| Database: |
BASE |