| Title: |
Effects of Physical Activity and Inactivity on Microvasculature in Children: The Hong Kong Children Eye Study |
| Authors: |
Zhang, Xiu Juan; Yuen, Vincent L.; Zhang, Yuzhou; Kam, Ka Wai; Wong, Jason; Tang, Fang Yao; Young, Alvin; Ip, Patrick; Chen, Li Jia; Wong, Tien Y.; Pang, Chi Pui; Tham, Clement C.; Cheung, Carol Y.; Yam, Jason C. |
| Publisher Information: |
Association for Research in Vision and Ophthalmology |
| Publication Year: |
2024 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Subject Terms: |
deep learning; paediatric ophthalmology; physical activity; retinal vasculature |
| Description: |
Purpose : The purpose of this study was to investigate the effects of physical activity and inactivity on the microvasculature in children, as measured from retinal photographs. Methods : All participants were from the Hong Kong Children Eye Study, a population-based cross-sectional study of children aged 6 to 8 years. They received comprehensive ophthalmic examinations and retinal photography. Their demographics and involvement in physical activity and inactivity were obtained from validated questionnaires. A validated Deep Learning System was used to measure, from retinal photographs, central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Results : In the final analysis of 11,959 participants, 6244 (52.2%) were boys and the mean age was 7.55 (1.05) years. Increased ratio of physical activity to inactivity was associated with wider CRAE ( β = 1.033, P = 0.007) and narrower CRVE ( β = –2.079, P < 0.001). In the subgroup analysis of boys, increased ratio of physical activity to inactivity was associated with wider CRAE ( β = 1.364, P = 0.013) and narrower CRVE ( β = –2.563, P = 0.001). The subgroup analysis of girls also showed increased ratio of physical activity to inactivity was associated with narrower CRVE ( β = –1.759, P = 0.020), but not CRAE. Conclusions : Increased activity in children is associated with healthier microvasculature, as shown in the retina. Our study contributes to the growing evidence that physical activity positively influences vascular health from a young age. Therefore, this study also underscores the potential of using the retinal vasculature as a biomarker of cardiovascular health. ; published_or_final_version |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Investigative Ophthalmology & Visual Science; Investigative Ophthalmology & Visual Science, 2024, v. 65, n. 14; WOS:001388959700001; 14; https://hub.hku.hk/handle/10722/355802; 65 |
| DOI: |
10.1167/iovs.65.14.7 |
| Availability: |
https://hub.hku.hk/handle/10722/355802; https://doi.org/10.1167/iovs.65.14.7 |
| Rights: |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.1755F013 |
| Database: |
BASE |